5-HT1A autoreceptor desensitization by chronic ultramild stress in mice

被引：87
作者：
Lanfumey, L
Pardon, MC
Laaris, N
Joubert, C
Hanoun, N
Hamon, M
Cohen-Salmon, C
机构：
[1] CHU Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France
[2] CHU Pitie Salpetriere, IFR Neurosci, CNRS 7593, F-75634 Paris, France
来源：
NEUROREPORT | 1999年 / 10卷 / 16期
关键词：
chronic ultramild stress; electrophysiology; 5-HT1A autoreceptors; serotonin; slice;
D O I：
10.1097/00001756-199911080-00021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
ELECTROPHYSIOLOGICAL and biochemical approaches were used to assess possible changes in central 5-HT neurotransmission in mice that had been subjected to chronic ultramild stress for 8 weeks. This treatment produced a significant decrease in the potency of the 5-HT1A agonist ipsapirone to inhibit the electrical activity of serotoninergic neurons in the dorsal raphe nucleus, without modifying 5-HT1A receptor binding in various brain areas. These data demonstrate that chronic ultra-mild stress triggers a long term and durable functional desensitization of somatodendritic 5-HT1A autoreceptors in mice. NeuroReport 10:3369-3374 (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码：3369 / 3374
页数：6
相关论文
共 50 条
[41]   5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse:: studies in 5-HT1B knock-out mice [J].
Evrard, A ;
Laporte, AM ;
Chastanet, M ;
Hen, R ;
Hamon, M ;
Adrien, J .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (11) :3823-3831
[42]   Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice [J].
Ueki, Toshiyuki ;
Mizoguchi, Kazushige ;
Yamaguchi, Takuji ;
Nishi, Akinori ;
Ikarashi, Yasushi ;
Hattori, Tomohisa ;
Kase, Yoshio .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015, 2015
[43]   Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex [J].
Centenaro, LA-gia Aline ;
Vieira, Karin ;
Zimmermann, Nicolle ;
Miczek, Klaus A. ;
Lucion, Aldo Bolten ;
Almeida, Rosa Maria Martins de .
PSYCHOPHARMACOLOGY, 2008, 201 (02) :237-248
[44]   Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex [J].
Lígia Aline Centenaro ;
Karin Vieira ;
Nicolle Zimmermann ;
Klaus A. Miczek ;
Aldo Bolten Lucion ;
Rosa Maria Martins de Almeida .
Psychopharmacology, 2008, 201
[45]   Investigating the Role of Serotonin in Methamphetamine Psychosis: Unaltered Behavioral Effects of Chronic Methamphetamine in 5-HT1A Knockout Mice [J].
Jaehne, Emily J. ;
Ameti, Dzeneta ;
Paiva, Tehani ;
van den Buuse, Maarten .
FRONTIERS IN PSYCHIATRY, 2017, 8
[46]   Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT1A Receptor with 5-HT3 Receptor Inhibition in Rats [J].
Okada, Motohiro ;
Okubo, Ruri ;
Fukuyama, Kouji .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (24)
[47]   5-Hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (Neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization [J].
Froger, N ;
Gardier, AM ;
Moratalla, R ;
Alberti, I ;
Lena, I ;
Boni, C ;
De Felipe, C ;
Rupniak, NMJ ;
Hunt, SP ;
Jacquot, C ;
Hamon, M ;
Lanfumey, L .
JOURNAL OF NEUROSCIENCE, 2001, 21 (20) :8188-8197
[48]   CHRONIC ALCOHOLIZATION ALTERS THE EXPRESSION OF 5-HT1A AND 5-HT1B RECEPTOR SUBTYPES IN RAT-BRAIN [J].
NEVO, I ;
LANGLOIS, X ;
LAPORTE, AM ;
KLEVEN, M ;
KOEK, W ;
LIMA, L ;
MAUDHUIT, C ;
MARTRES, MP ;
HAMON, M .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 281 (03) :229-239
[49]   Electroacupuncture improves synaptic plasticity by regulating the 5-HT1A receptor in hippocampus of rats with chronic unpredictable mild stress [J].
Chen, Lixing ;
Yao, Zengyu ;
Qu, Shanshan ;
Zhang, Jialing ;
Zhang, Jiping ;
Zhang, Zhinan ;
Huang, Yong ;
Zhong, Zheng .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2020, 48 (05)
[50]   Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice [J].
Emily Freeman-Daniels ;
Sheryl G. Beck ;
Lynn G. Kirby .
Psychopharmacology, 2011, 213 :453-463
12345