ZnO Nanowire Arrays on 3D Hierachical Graphene Foam: Biomarker Detection of Parkinson's Disease

被引：267

作者：

Yue, Hong Yan ^{[1
,2
,3
]}

Huang, Shuo ^{[4
]}

Chang, Jian ^{[1
,2
]}

Heo, Chaejeong ^{[5
]}

Yao, Fei ^{[1
,2
]}

Adhikari, Subash ^{[1
,2
]}

Gunes, Fethullah ^{[2
]}

Liu, Li Chun ^{[2
]}

Lee, Tae Hoon ^{[1
,2
]}

Oh, Eung Seok ^{[6
]}

Li, Bing ^{[1
,2
]}

Zhang, Jian Jiao ^{[3
]}

Ta Quang Huy ^{[1
,2
]}

Nguyen Van Luan ^{[1
,2
]}

Lee, Young Hee ^{[1
,2
]}

机构：

[1] Sungkyunkwan Univ, Inst Basic Sci, Ctr Integrated Nanostruct Phys, Suwon 440746, South Korea

[2] Sungkyunkwan Univ, Dept Phys, Dept Energy Sci, Suwon 440746, South Korea

[3] Harbin Univ Sci & Technol, Sch Mat Sci & Engn, Harbin 150040, Peoples R China

[4] Harbin Med Univ, Dept Neurol, Affiliated Hosp 1, Harbin 150001, Peoples R China

[5] Sungkyunkwan Univ, Inst Basic Sci, Ctr Neurosci Imaging Res, Suwon 440746, South Korea

[6] Chungnam Natl Univ, Chungnam Natl Univ Hosp, Sch Med, Dept Neurol, Taejon 103721, South Korea

来源：

ACS NANO | 2014年 / 8卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

ZnO nanowire arrays; graphene foam; biosensor; biomarker detection; Parkinson's disease; ASCORBIC-ACID; ELECTROCHEMICAL DETECTION; URIC-ACID; DOPAMINE; URATE;

D O I：

10.1021/nn405961p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson's disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.

引用

页码：1639 / 1646

页数：8

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