Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

被引：10

作者：

de Seymour, Jamie V. ^{[1
]}

Tu, Stephanie ^{[1
,2
]}

He, Xiaoling ^{[3
]}

Zhang, Hua ^{[3
]}

Han, Ting-Li ^{[1
,3
]}

Baker, Philip N. ^{[1
,3
,4
]}

Sulek, Karolina ^{[1
,5
]}

机构：

[1] Univ Auckland, Liggins Inst, Auckland, New Zealand

[2] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden

[3] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynaecol, Chongqing, Peoples R China

[4] Univ Leicester, Coll Life Sci, Leicester, Leics, England

[5] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark

来源：

METABOLOMICS | 2018年 / 14卷 / 06期

关键词：

Intrahepatic cholestasis of pregnancy; Metabolomics; Hair; Gas chromatography-mass spectrometry; IDENTIFICATION; SPECTROMETRY; DISCOVERY;

D O I：

10.1007/s11306-018-1371-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Investigate the maternal hair metabolome for predictive biomarkers of ICP. The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography-mass spectrometry. Of 105 metabolites detected in hair, none were significantly associated with ICP. Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

引用

页数：5

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