Head and Neck Squamous Cell Carcinoma: Prognosis using molecular approach

被引：6

作者：

Mazumder, Tarikul Huda ^{[1
]}

Nath, Sayantan ^{[1
]}

Nath, Nibendu ^{[1
]}

Kumar, Munish ^{[1
,2
]}

机构：

[1] Assam Univ, Dept Biotechnol, Silchar 788011, Assam, India

[2] Univ Allahabad, Dept Biochem, Allahabad 211002, Uttar Pradesh, India

来源：

CENTRAL EUROPEAN JOURNAL OF BIOLOGY | 2014年 / 9卷 / 06期

关键词：

Head and neck squamous cell carcinoma; DNA repair genes; Glutathione S-transferases; p53; mutations; Risk factors; DNA-REPAIR GENES; SINGLE-NUCLEOTIDE POLYMORPHISMS; BASE-EXCISION-REPAIR; STRAND BREAK REPAIR; S-TRANSFERASE M1; LUNG-CANCER RISK; P53; GENE; ORAL-CANCER; IONIZING-RADIATION; LIFE-STYLE;

D O I：

10.2478/s11535-014-0292-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) is the fifth most prevalent cancer worldwide. Apart from various known clinicopathogical factors, it is still a major concern as many genetic and epigenetic alterations bring about the possibility of this deadly disease. The aim of this review is to explore the possible role of DNA repair pathways and the polymorphic status of DNA repair genes (XPA, XPC, XPD, XRCC1 and XRCC3) in the onset of HNSCC, along with sequence variations in genes such as Glutathione S-transferases (GSTT1, M1 and P1) that are significantly associated with HNSCC risk. We also focus on the p53 gene mutation induced by various etiological agents and threat factors with its implications towards HNSCC, and emphasise the current therapeutic interventions in treating HNSCC.

引用

页码：593 / 613

页数：21

共 137 条

[1] Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes [J].

Abbasi, Rashda ;

Ramroth, Heribert ;

Becher, Heiko ;

Dietz, Andreas ;

Schmezer, Peter ;

Popanda, Odilia .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (06) :1431-1439

[2]

Aggarwal BB, 2004, ANTICANCER RES, V24, P2783

[3] Potentially functional single nucleoticle polymorphisms in the core nucleoticle excision repair genes and risk of squamous cell carcinoma of the head and neck [J].

An, Jiaze ;

Liu, Zhensheng ;

Hu, Zhibin ;

Li, Guojun ;

Wang, Li-E ;

Sturgis, Erich M. ;

El-Naggar, Adel K. ;

Spitz, Margaret R. ;

Wei, Qingyi .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (08) :1633-1638

[4] Effects of Temperature on the p53-DNA Binding Interactions and Their Dynamical Behavior: Comparing the Wild Type to the R248Q Mutant [J].

Barakat, Khaled ;

Issack, Bilkiss B. ;

Stepanova, Maria ;

Tuszynski, Jack .

PLOS ONE, 2011, 6 (11)

[5]

Bau DT, 2007, CHINESE J PHYSIOL, V50, P294

[6] Curcumin and Other Polyphenolic Compounds in Head and Neck Cancer Chemoprevention [J].

Baumeister, Philipp ;

Reiter, Maximilian ;

Harreus, Ulrich .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2012, 2012

[7] The Origins and Evolution of the p53 Family of Genes [J].

Belyi, Vladimir A. ;

Ak, Prashanth ;

Markert, Elke ;

Wang, Haijian ;

Hu, Wenwei ;

Puzio-Kuter, Anna ;

Levine, Arnold J. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (06) :a001198

[8] TP53 family members and human cancers [J].

Bénard, J ;

Douc-Rasy, S ;

Ahomadegbe, JC .

HUMAN MUTATION, 2003, 21 (03) :182-191

[9]

Bongers V, 1996, CANCER EPIDEM BIOMAR, V5, P595

[10]

Cadoni G, 2012, ACTA OTORHINOLARYNGO, V32, P1

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