Epicardial Control of Myocardial Proliferation and Morphogenesis

被引：47
作者：
Sucov, Henry M. [1 ]
Gu, Ying [1 ]
Thomas, Simmy [1 ]
Li, Peng [1 ]
Pashmforoush, Mohammad [1 ]
机构：
[1] Univ So Calif, Keck Sch Med, Inst Med Genet, Los Angeles, CA 90033 USA
来源：
PEDIATRIC CARDIOLOGY | 2009年 / 30卷 / 05期
关键词：
Compact zone; Epicardium; Heart development; CORONARY-ARTERY FORMATION; X-RECEPTOR-ALPHA; CARDIAC DEVELOPMENT; HEART DEVELOPMENT; EMBRYONIC HEART; VASCULAR DEVELOPMENT; RETINOIC ACID; GROWTH-FACTOR; TGF-BETA; MYOCYTE PROLIFERATION;
D O I：
10.1007/s00246-009-9391-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.
引用
收藏
页码：617 / 625
页数：9
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