Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract 2018 Update

被引：5

作者：

Zhang, Lei ^{[1
]}

Bluth, Martin H. ^{[2
,3
]}

Bhalla, Amarpreet ^{[4
]}

机构：

[1] Univ Buffalo, Buffalo Gen Hosp, Jacobs Sch Med & Biomed Sci, Dept Pathol & Anat Sci, 100 High St, Buffalo, NY 14203 USA

[2] Wayne State Univ, Dept Pathol, Sch Med, 540 East Canfield St, Detroit, MI 48201 USA

[3] Michigan Surg Hosp, Pathol Labs, 21230 Dequindre Rd, Warren, MI 48091 USA

[4] Univ Buffalo SUNY, Dept Pathol & Anat Sci, Jacobs Sch Med & Biomed Sci, Buffalo Gen Hosp A-701,100 High St, Buffalo, NY 14203 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2018年 / 38卷 / 02期

关键词：

Pancreatic neoplasms; Liver; Hepatic adenoma; Hepatocellular carcinoma; Cholangiocarcinoma; Molecular diagnostics; Cell free nucleic acid; ACINAR-CELL-CARCINOMA; SPORADIC NEUROENDOCRINE TUMORS; PAPILLARY MUCINOUS NEOPLASMS; DNA-REPAIR GENES; K-RAS; BETA-CATENIN; HEPATOCELLULAR ADENOMA; MALIGNANT-TRANSFORMATION; P53; OVEREXPRESSION; CYSTIC NEOPLASMS;

D O I：

10.1016/j.cll.2018.03.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and cholangiocarcinoma display heterogeneity at both morphologic and molecular levels. Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.

引用

页码：367 / +

页数：19

共 107 条

[1] Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor β-catenin mutations [J].