Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion

被引:22
作者
Curiel, Laura [1 ,2 ]
Huang, Yuexi [1 ]
Vykhodtseva, Natalia [3 ]
Hynynen, Kullervo [1 ]
机构
[1] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada
[2] Thunder Bay Reg Res Inst, High Intens Focused Ultrasound HIFU Lab, Toronto, ON P7C 1M5, Canada
[3] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
关键词
IN-VIVO; PROSTATE-CANCER; TEMPERATURE; SURGERY; LESIONS; MRI; ELASTOGRAPHY; THERMOMETRY; DOSIMETRY; ABLATION;
D O I
10.1088/0031-9155/54/11/009
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The purpose of this study was to evaluate the feasibility of using localized harmonic motion (LHM) to monitor and control focused ultrasound surgery (FUS) in VX2 tumors in vivo. FUS exposures were performed on 13 VX2 tumors implanted in nine rabbits. The same transducer induced coagulation and generated a localized oscillatory motion by periodically varying the radiation force. A separate diagnostic ultrasound transducer tracked motion by cross-correlating echo signals at different instances. A threshold inmotion amplitude was instituted to cease exposure. Coagulation was confirmed by T2-weighted MR images, thermal dose obtained through MR thermometry and histological examinations. For tumor locations achieving coagulation, the LHM amplitude was 9% (p = 0.04) to 57% (p < 0.0001) lower than that before exposure. Control was successful for 74 (69%) out of 108 cases, with 52 (48%) reaching the threshold and achieving coagulation and 22 (21%) never reaching threshold nor coagulating. For the 34 (31%) unsuccessful exposures, 16 (15%) never reached the threshold but coagulation occurred, and 18 (16%) reached threshold without coagulation confirmed. Noise or radio-frequency signal changes explained motion over- or underestimation in 24 (22%) cases; the remaining 10 (9%) had other causes of error. The control was generally successful, but sudden change or noise in the acquired echo signal caused failure. Coagulation after exposure could be validated by comparing amplitudes before and after exposure.
引用
收藏
页码:3405 / 3419
页数:15
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