Antimicrobial Stewardship in the NICU

被引：90

作者：

Cantey, Joseph B. ^{[1
,2
]}

Patel, Sameer J. ^{[3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pediat, Div Pediat Infect Dis, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pediat, Div Neonatal Perinatal Med, Dallas, TX 75390 USA

[3] Northwestern Univ, Feinberg Sch Med, Ann & Robert H Lurie Childrens Hosp Chicago, Div Pediat Infect Dis,Dept Pediat, Chicago, IL 60611 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 02期

关键词：

Neonatal intensive care unit; Stewardship; Antimicrobial; Metrics; INTENSIVE-CARE-UNIT; LATE-ONSET SEPSIS; EMPIRICAL ANTIBIOTIC-TREATMENT; C-REACTIVE PROTEIN; UNDER-THE-CURVE; NECROTIZING ENTEROCOLITIS; PRETERM INFANTS; NEONATAL SEPSIS; RISK-FACTORS; BLOOD-COUNT;

D O I：

10.1016/j.idc.2014.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There are unique challenges to antimicrobial stewardship in neonatal intensive care units (NICUs). Diagnosis of infection is difficult as neonates can have nonspecific signs and symptoms. Between and within NICUs, significant variation exists in the treatment duration of suspected sepsis and pneumonia. Development of multidisciplinary teams and meaningful metrics are essential for sustainable antibiotic stewardship. Potential stewardship interventions include optimizing culturing techniques, guiding empiric therapy by NICU-specific antibiograms, using ancillary laboratory tests, and promptly discontinuing therapy once infection is no longer suspected. Use of large neonatal databases can be used to benchmark antibiotic use and conduct comparative effectiveness research.

引用

页码：247 / +

页数：16

共 85 条

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