LhARA: The Laser-hybrid Accelerator for Radiobiological Applications

被引：27

作者：

Aymar, Galen ^{[1
]}

Becker, Tobias ^{[2
]}

Boogert, Stewart ^{[3
]}

Borghesi, Marco ^{[4
]}

Bingham, Robert ^{[1
,5
]}

Brenner, Ceri ^{[1
]}

Burrows, Philip N. ^{[6
]}

Ettlinger, Oliver C. ^{[7
]}

Dascalu, Titus ^{[8
]}

Gibson, Stephen ^{[3
]}

Greenshaw, Timothy ^{[9
]}

Gruber, Sylvia ^{[10
]}

Gujral, Dorothy ^{[11
]}

Hardiman, Claire ^{[11
]}

Hughes, Jonathan ^{[9
]}

Jones, W. G. ^{[8
,12
]}

Kirkby, Karen ^{[13
]}

Kurup, Ajit ^{[8
]}

Lagrange, Jean-Baptiste ^{[1
]}

Long, Kenneth ^{[1
,8
]}

Luk, Wayne ^{[8
]}

Matheson, John ^{[1
]}

McKenna, Paul ^{[5
,14
]}

McLauchlan, Ruth ^{[11
]}

Najmudin, Zulfikar ^{[7
]}

Lau, Hin T. ^{[8
]}

Parsons, Jason L. ^{[15
,16
]}

Pasternak, Jaroslaw ^{[1
,8
]}

Pozimski, Juergen ^{[1
,8
]}

Prise, Kevin ^{[17
]}

Puchalska, Monika ^{[18
]}

Ratoff, Peter ^{[14
,24
]}

Schettino, Giuseppe ^{[19
,20
]}

Shields, William ^{[3
]}

Smith, Susan ^{[21
]}

Thomason, John ^{[1
]}

Towe, Stephen ^{[22
]}

Weightman, Peter ^{[8
]}

Whyte, Colin ^{[5
]}

Xiao, Rachel ^{[23
]}

机构：

[1] STFC Rutherford Appleton Lab, Didcot, Oxon, England

[2] Maxeier Technol Ltd, London, England

[3] Royal Holloway Univ London, John Adams Inst Accelerator Sci, Egham, Surrey, England

[4] Queens Univ Belfast, Ctr Plasma Phys, Dept Phys, Belfast, Antrim, North Ireland

[5] Univ Strathclyde, Dept Phys, SUPA, Glasgow, Lanark, Scotland

[6] Univ Oxford, John Adams Inst Accelerator Sci, Oxford, England

[7] Imperial Coll London, John Adams Inst Accelerator Sci, London, England

[8] Imperial Coll London, Dept Phys, London, England

[9] Univ Liverpool, Dept Phys, Liverpool, Merseyside, England

[10] Med Univ Vienna, Christian Doppler Lab Med Radiat Res Radiat Oncol, Vienna, Austria

[11] Bays St Marys Hosp, Imperial Coll Healthcare NHS Trust, London, England

[12] Imperial Coll London, Imperial Patient & Publ Involvement Grp, London, England

[13] Univ Manchester, Sch Med Sci, Div Canc Sci, Manchester, Lancs, England

[14] Cockcroft Inst, Daresbury Lab, Sci Tech Daresbury, Liverpool, Merseyside, England

[15] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England

[16] Clatterbridge Canc Ctr, Liverpool, Merseyside, England

[17] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Canc Res Cell Biol, Belfast, Antrim, North Ireland

[18] Tech Univ Wien, Atominst, Vienna, Austria

[19] Natl Phys Lab, London, England

[20] Univ Surrey, London, England

[21] STFC Daresbury Lab, Liverpool, Merseyside, England

[22] Leo Canc Care, London, England

[23] Corerain Technol, Shenzhen, Peoples R China

[24] Univ Lancaster, Phys Dept, Lancaster, England

来源：

FRONTIERS IN PHYSICS | 2020年 / 8卷

基金：

英国科学技术设施理事会;

关键词：

radiobiology; novel acceleration; proton beam therapy (PBT); ion beam therapy; laser-driven acceleration; plasma lens; fixed-field alternating-gradient acceleration; RELATIVE BIOLOGICAL EFFECTIVENESS; PROTON-BEAM; DOSE-RATE; ION; IRRADIATION; THERAPY; TRANSPORT; GENERATION; DOSIMETRY; SELECTION;

D O I：

10.3389/fphy.2020.567738

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The "Laser-hybrid Accelerator for Radiobiological Applications," LhARA, is conceived as a novel, flexible facility dedicated to the study of radiobiology. The technologies demonstrated in LhARA, which have wide application, will be developed to allow particle-beam therapy to be delivered in a new regimen, combining a variety of ion species in a single treatment fraction and exploiting ultra-high dose rates. LhARA will be a hybrid accelerator system in which laser interactions drive the creation of a large flux of protons or light ions that are captured using a plasma (Gabor) lens and formed into a beam. The laser-driven source allows protons and ions to be captured at energies significantly above those that pertain in conventional facilities, thus evading the current space-charge limit on the instantaneous dose rate that can be delivered. The laser-hybrid approach, therefore, will allow the radiobiology that determines the response of tissue to ionizing radiation to be studied with protons and light ions using a wide variety of time structures, spectral distributions, and spatial configurations at instantaneous dose rates up to and significantly beyond the ultra-high dose-rate "FLASH" regime. It is proposed that LhARA be developed in two stages. In the first stage, a programme ofin vitroradiobiology will be served with proton beams with energies between 10 and 15 MeV. In stage two, the beam will be accelerated using a fixed-field alternating-gradient accelerator (FFA). This will allow experiments to be carried outin vitroandin vivowith proton beam energies of up to 127 MeV. In addition, ion beams with energies up to 33.4 MeV per nucleon will be available forin vitroandin vivoexperiments. This paper presents the conceptual design for LhARA and the R&D programme by which the LhARA consortium seeks to establish the facility.

引用

页数：21

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