Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine

被引：32
作者：
Liu, Lin-Sheng [1 ]
Liu, Meng-Hua [2 ]
He, Jing-Yu [3 ]
机构：
[1] Foshan Hosp Tradit Chinese Med, Dept Pharm, Foshan 528000, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
[3] Chinese Acad Sci, Guangzhou Inst Adv Technol, Guangzhou 511458, Guangdong, Peoples R China
来源：
MOLECULES | 2014年 / 19卷 / 08期
关键词：
Hypericum japonicum; phytochemistry; pharmacology; quality control; pharmacokinetics; PHLOROGLUCINOL DERIVATIVES; FLAVONOIDS; EXTRACT;
D O I：
10.3390/molecules190810733
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hypericum japonicum Thunb. ex Murray is mainly distributed throughout Asia, Oceania and North America and is used as an important herbal medicine. H. japonicum contains many valuable secondary metabolites, such as flavonoids, phloroglucinols and xanthones and has hepatoprotective, anti-tumor, antibacterial, antiviral, and antioxidant activities and effects on the cardiovascular system and immunity. Coupled with phytochemical and pharmacological research, a series of analytical methods have been developed to evaluate the quality of H. japonicum based on its bioactive components. A pharmacokinetics study involved the absorption of two main flavonoids of H. japonicum in rats. This review aims to present an up-to-date and comprehensive overview of the phytochemistry, pharmacology, quality control and pharmacokinetics of H. japonicum, which should be useful for the greater development of H. japonicum, especially in the development of new drugs and therapeutics for various diseases.
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页码：10733 / 10754
页数：22
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