A relaxin-based nanotherapy for liver fibrosis

被引：11

作者：

Fallowfield, Jonathan A. ^{[1
]}

Ramachandran, Prakash ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland

来源：

NATURE NANOTECHNOLOGY | 2021年 / 16卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/s41565-020-00832-w

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Targeting of the peptide hormone relaxin to injured mouse liver, via a nanoparticle/gene therapy approach, switches pro-fibrotic hepatic macrophages to a restorative phenotype that orchestrates tissue repair.

引用

页码：365 / 366

页数：2

共 12 条

[1] Relaxin decreases the severity of established hepatic fibrosis in mice [J].

Bennett, Robert G. ;

Heimann, Dean G. ;

Singh, Sudhir ;

Simpson, Ronda L. ;

Tuma, Dean J. .

LIVER INTERNATIONAL, 2014, 34 (03) :416-426

[2] Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling [J].

Chen, Lei ;

Sha, Ming-Lei ;

Li, Deng ;

Zhu, Yi-Ping ;

Wang, Xing-Jie ;

Jiang, Chen-Yi ;

Xia, Shu-Jie ;

Shao, Yi .

ONCOTARGET, 2017, 8 (13) :21044-21053

[3] Relaxin Modulates Human and Rat Hepatic Myofibroblast Function and Ameliorates Portal Hypertension In Vivo [J].

Fallowfield, Jonathan A. ;

Hayden, Annette L. ;

Snowdon, Victoria K. ;

Aucott, Rebecca L. ;

Stutchfield, Ben M. ;

Mole, Damian J. ;

Pellicoro, Antonella ;

Gordon-Walker, Timothy T. ;

Henke, Alexander ;

Schrader, Joerg ;

Trivedi, Palak J. ;

Princivalle, Marc ;

Forbes, Stuart J. ;

Collins, Jane E. ;

Iredale, John P. .

HEPATOLOGY, 2014, 59 (04) :1492-1504

[4] Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis [J].

Hu, Mengying ;

Wang, Ying ;

Liu, Zhengsheng ;

Yu, Zhuo ;

Guan, Kaiyun ;

Liu, Mengrui ;

Wang, Menglin ;

Tan, Jun ;

Huang, Leaf .

NATURE NANOTECHNOLOGY, 2021, 16 (04) :466-+

[5] Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis [J].

Kaftanovskaya, Elena M. ;

Ng, Hooi Hooi ;

Soula, Mariluz ;

Rivas, Bryan ;

Myhr, Courtney ;

Ho, Brian A. ;

Cervantes, Briana A. ;

Shupe, Thomas D. ;

Devarasetty, Mahesh ;

Hu, Xin ;

Xu, Xin ;

Patnaik, Samarjit ;

Wilson, Kenneth J. ;

Barnaeva, Elena ;

Ferrer, Marc ;

Southall, Noel T. ;

Marugan, Juan J. ;

Bishop, Colin E. ;

Agoulnik, Irina U. ;

Agoulnik, Alexander I. .

FASEB JOURNAL, 2019, 33 (11) :12435-12446

[6] A single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats [J].

Kim, Ja Kyung ;

Lee, Jung Il ;

Paik, Yong-Han ;

Yun, Chae-Ok ;

Chang, Hye Young ;

Lee, Su Yeon ;

Lee, Kwan Sik .

JOURNAL OF GENE MEDICINE, 2016, 18 (1-3) :16-26

[7] Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease [J].

Lee, Kuei-Chuan ;

Hsieh, Yun-Cheng ;

Chan, Che-Chang ;

Sun, Hao-Jhe ;

Huang, Yi-Hsiang ;

Hou, Ming-Chih ;

Lin, Han-Chieh .

LABORATORY INVESTIGATION, 2019, 99 (08) :1203-1216

[8] Engineered Relaxin as theranostic nanomedicine to diagnose and ameliorate liver cirrhosis [J].

Nagorniewicz, Beata ;

Mardhian, Deby F. ;

Booijink, Richell ;

Storm, Gert ;

Prakash, Jai ;

Bansal, Ruchi .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2019, 17 :106-118

[9] Liver fibrosis and repair: immune regulation of wound healing in a solid organ [J].

Pellicoro, Antonella ;

Ramachandran, Prakash ;

Iredale, John P. ;

Fallowfield, Jonathan A. .

NATURE REVIEWS IMMUNOLOGY, 2014, 14 (03) :181-194

[10] Resolving the fibrotic niche of human liver cirrhosis at single-cell level [J].

Ramachandran, P. ;

Dobie, R. ;

Wilson-Kanamori, J. R. ;

Dora, E. F. ;

Henderson, B. E. P. ;

Luu, N. T. ;

Portman, J. R. ;

Matchett, K. P. ;

Brice, M. ;

Marwick, J. A. ;

Taylor, R. S. ;

Efremova, M. ;

Vento-Tormo, R. ;

Carragher, N. O. ;

Kendall, T. J. ;

Fallowfield, J. A. ;

Harrison, E. M. ;

Mole, D. J. ;

Wigmore, S. J. ;

Newsome, P. N. ;

Weston, C. J. ;

Iredale, J. P. ;

Tacke, F. ;

Pollard, J. W. ;

Ponting, C. P. ;

Marioni, J. C. ;

Teichmann, S. A. ;

Henderson, N. C. .

NATURE, 2019, 575 (7783) :512-+

← 1 2 →