A member of the frizzled protein family mediating axis induction by Wnt-5A

被引：406

作者：

He, X

SaintJeannet, JP

Wang, YS

Nathans, J

Dawid, I

Varmus, H

机构：

[1] NCI,NIH,BETHESDA,MD 20892

[2] NICHHD,NIH,BETHESDA,MD 20892

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MOL BIOL & GENET,HOWARD HUGHES MED INST,BALTIMORE,MD 21205

来源：

SCIENCE | 1997年 / 275卷 / 5306期

关键词：

D O I：

10.1126/science.275.5306.1652

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis duplication, whereas the Wnt-5A subclass does not. This difference could be explained by distinct signal transduction pathways or by a lack of one or more Wnt-5A receptors during axis formation. Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors. Wnt-5A/hFz5 signaling was antagonized by glycogen synthase kinase-3 and by the amino-terminal ectodomain of hFz5. These results identify hFz5 as a receptor for Wnt-5A.

引用

页码：1652 / 1654

页数：3

共 29 条

[1] A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].