Study of H/D exchange rates to derive the strength of intramolecular hydrogen bonds in halo substituted organic building blocks: An NMR spectroscopic investigation

被引：8

作者：

Mishra, Sundeep Kumar

Suryaprakash, N. ^{[1
]}

机构：

[1] Indian Inst Sci, NMR Res Ctr, Bangalore 560012, Karnataka, India

来源：

CHEMICAL PHYSICS LETTERS | 2015年 / 639卷

关键词：

ASYMMETRIC CATALYSIS; DEUTERIUM-EXCHANGE; BASE-PAIRS; PEPTIDOMIMETICS; PEPTIDES; DESIGN; MECHANISM; NETWORKS; SYSTEMS; AMIDES;

D O I：

10.1016/j.cplett.2015.09.038

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Rates of hydrogen/deuterium (H/D) exchange determined by H-1 NMR spectroscopy are utilized to derive the strength of hydrogen bonds and to monitor the electronic effects in the site-specific halogen substituted benzamides and anilines. The theoretical fitting of the time dependent variation of the integral areas of H-1 NMR resonances to the first order decay function permitted the determination of HID exchange rate constants (k) and their precise half-lives (t(1/2)) with high degree of reproducibility. The comparative study also permitted the unambiguous determination of relative strength of hydrogen bonds and the contribution from electronic effects on the HID exchange rate. (C) 2015 Elsevier B.V. All rights reserved.

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页码：254 / 260

页数：7

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