Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

被引：78
作者：
Hong, GY
Baudhuin, LM
Xu, Y
机构：
[1] Cleveland Clin Fdn, Dept Canc Biol, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Obstet & Gynecol, Cleveland, OH 44195 USA
[3] Cleveland State Univ, Dept Chem, Cleveland, OH 44115 USA
来源：
FEBS LETTERS | 1999年 / 460卷 / 03期
关键词：
sphinyosine-1-phosphate (SIP); lysophosphatidic acid (LPA); ovarian cancer; cell adhesion; aggregation;
D O I：
10.1016/S0014-5793(99)01400-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-mu M to mu M concentrations of SIP in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. SIP (10 mu M) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 mu M also induced calcium-dependent cell-cell aggregation. (C) 1999 Federation of European Biochemical Societies.
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页码：513 / 518
页数：6
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