Accelerated drug discovery by rapid candidate drug identification

被引:28
作者
Bergstrom, Fredrik [1 ]
Lindmark, Bo [1 ]
机构
[1] AstraZeneca, IMED Biotech Unit, Drug Metab & Pharmacokinet, Cardiovasc Renal & Metab, Gothenburg, Sweden
关键词
LIGAND EFFICIENCY; IN-VITRO; QUALITY; LESSONS; DESIGN;
D O I
10.1016/j.drudis.2019.03.026
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The eventual candidate drug (CD) is often already synthesized during early drug discovery but not nominated until much later. To facilitate the rapid identification of a potential CD, a thoroughly worked-out CD target profile (CDTP) with criteria acceptable for the disease target product profile (TPP) is required at the start of lead generation (LG). In addition to driving the compound property optimization, the preclinical project team has to understand the ultimate goal to be able to rapidly identify and progress a potential CD. A screening cascade with meaningful and well-balanced progression criteria based on the CDTP is required to rapidly filter out unwanted compounds and to progress a potential CD through the cascade to candidate selection.
引用
收藏
页码:1237 / 1241
页数:5
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