The possible role of gastrointestinal endocrine cells in the pathophysiology of irritable bowel syndrome

被引：30
作者：
El-Salhy, Magdy [1 ,2 ,3 ]
Hausken, Trygve [2 ,3 ]
Gilja, Odd Helge [2 ,3 ,4 ]
Hatlebakk, Jan Gunnar [2 ,3 ]
机构：
[1] Stord Hosp, Div Gastroenterol, Dept Med, Stord, Norway
[2] Univ Bergen, Div Gastroenterol, Dept Clin Med, Bergen, Norway
[3] Haukeland Hosp, Dept Med, Natl Ctr Funct Gastrointestinal Disorders, Bergen, Norway
[4] Haukeland Hosp, Dept Med, Natl Ctr Ultrasound Gastroenterol, Bergen, Norway
来源：
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2017年 / 11卷 / 02期
关键词：
Diet; genes; low-grade inflammation; neurogenin; 3; Musashi-1; microbiota; stem cells; DEXTRAN SULFATE SODIUM; NEURAL CREST CELLS; IBS-LIKE SYMPTOMS; QUALITY-OF-LIFE; CHROMOGRANIN-A; PEPTIDE YY; ENTEROENDOCRINE CELLS; ENTEROCHROMAFFIN CELL; STEM-CELLS; CHRONIC CONSTIPATION;
D O I：
10.1080/17474124.2017.1269601
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Introduction: The etiology of irritable bowel syndrome (IBS) is unknown, but several factors appear to play a role in its pathophysiology, including abnormalities of the gastrointestinal endocrine cells. The present review illuminates the possible role of gastrointestinal hormones in the pathophysiology of IBS and the possibility of utilizing the current knowledge in treating the disease.Areas covered: Research into the intestinal endocrine cells and their possible role in the pathophysiology of IBS is discussed. Furthermore, the mechanisms underlying the abnormalities in the gastrointestinal endocrine cells in IBS patients are revealed.Expert commentary: The abnormalities observed in the gastrointestinal endocrine cells in IBS patients explains their visceral hypersensitivity, gastrointestinal dysmotility, and abnormal intestinal secretion, as well as the interchangeability of symptoms over time. Clarifying the role of the intestinal stem cells in the pathophysiology of IBS may lead to new treatment methods for IBS.
引用
收藏
页码：139 / 148
页数：10
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