DNA Hydrogel by Multicomponent Assembly for Encapsulation and Killing of Cells

被引：26

作者：

Hu, Rong ^{[1
]}

Yuan, Huanxiang ^{[1
]}

Wang, Bing ^{[1
]}

Liu, Libing ^{[1
]}

Lv, Fengting ^{[1
]}

Wang, Shu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2014年 / 6卷 / 15期

基金：

中国国家自然科学基金;

关键词：

DNA; cationic conjugated polymers; self-assembly; therapeutic hydrogel; cell encapsulation; SOLUBLE CONJUGATED POLYMERS; LIGHT; POLYELECTROLYTES; NANOPARTICLES; ANTICANCER; COMPLEXES; RELEASE; CALCIUM;

D O I：

10.1021/am502196h

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this work, a new multifunctional assembled hydrogel was prepared by incorporating gadolinium ions (Gd3+) with salmon-sperm DNA and polythiophene derivative (PT-COOH) through chelation interactions. Efficient energy transfer from PT-COOH to Gd3+ ions takes place followed by sensitization of oxygen molecule to generate reactive oxygen species (ROS) under light irradiation. Cancer cells can be encapsulated into the hydrogel in situ as the formation of hydrogel followed by killing by the ROS. Integration of imaging modality with therapeutic function within a single assembled hydrogel is therefore anticipated to be a new and challenging design element for new hydrogel materials.

引用

页码：11823 / 11828

页数：6

共 34 条

[1] Two-component hydrogels comprising fatty acids and amines: Structure, properties, and application as a template for the synthesis of metal nanoparticles [J].

Basit, Haira ;

Pal, Asish ;

Sen, Saikat ;

Bhattacharya, Santanu .

CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (21) :6534-6545

[2] Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells [J].

Benoit, Danielle S. W. ;

Schwartz, Michael P. ;

Durney, Andrew R. ;

Anseth, Kristi S. .

NATURE MATERIALS, 2008, 7 (10) :816-823

[3] Gold Nanoparticle-Fluorophore Complexes: Sensitive and Discerning "Noses" for Biosystems Sensing [J].

Bunz, Uwe H. F. ;

Rotello, Vincent M. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (19) :3268-3279

[4] A strategy for antimicrobial regulation based on fluorescent conjugated oligomer-DNA hybrid hydrogels [J].

Cao, Ali ;

Tang, Yanli ;

Liu, Yue ;

Yuan, Huanxiang ;

Liu, Libing .

CHEMICAL COMMUNICATIONS, 2013, 49 (49) :5574-5576

[5] Sensitized luminescent terbium nanoparticles: Preparation and time-resolved fluorescence assay for DNA [J].

Chen, Yang ;

Chi, Yumei ;

Wen, Hongmei ;

Lu, Zuhong .

ANALYTICAL CHEMISTRY, 2007, 79 (03) :960-965

[6]

Choi M, 2013, NAT PHOTONICS, V7, P987, DOI [10.1038/NPHOTON.2013.278, 10.1038/nphoton.2013.278]

[7] Insight into the Mechanism of Antimicrobial Conjugated Polyelectrolytes: Lipid Headgroup Charge and Membrane Fluidity Effects [J].

Ding, Liping ;

Chi, Eva Y. ;

Schanze, Kirk S. ;

Lopez, Gabriel P. ;

Whitten, David G. .

LANGMUIR, 2010, 26 (08) :5544-5550

[8] Drug-sensing hydrogels for the inducible release of biopharmaceuticals [J].

Ehrbar, Martin ;

Schoenmakers, Ronald ;

Christen, Erik H. ;

Fussenegger, Martin ;

Weber, Wilfried .

NATURE MATERIALS, 2008, 7 (10) :800-804

[9] The effect of particle design on cellular internalization pathways [J].

Gratton, Stephanie E. A. ;

Ropp, Patricia A. ;

Pohlhaus, Patrick D. ;

Luft, J. Christopher ;

Madden, Victoria J. ;

Napier, Mary E. ;

DeSimone, Joseph M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (33) :11613-11618

[10] Water-Soluble Conjugated Polymers for Amplification of One- and Two-photon Properties of Photosensitizers [J].

He, Fang ;

Ren, Xinsheng ;

Shen, Xiaoqin ;

Xu, Qing-Hua .

MACROMOLECULES, 2011, 44 (13) :5373-5380

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