Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

被引：223
作者：
Arthur, Agnieszka [1 ,2 ]
Gronthos, Stan [1 ,2 ]
机构：
[1] Univ Adelaide, Adelaide Med Sch, Fac Hlth & Med Sci, Mesenchymal Stem Cell Lab, Adelaide, SA 5001, Australia
[2] South Australian Hlth & Med Res Inst, Precis Med Theme, Adelaide, SA 5001, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 24期
基金：
英国医学研究理事会;
关键词：
bone marrow mesenchymal stem cells; bone marrow microenvironment; skeletal tissue regeneration; tissue engineering; scaffolds; biomaterials; ENDOTHELIAL PROGENITOR CELLS; PARATHYROID-HORMONE; 1-34; STEM-CELLS; OSTEOGENESIS IMPERFECTA; STROMAL CELLS; IN-VITRO; MORPHOGENETIC PROTEIN-2; SUSTAINED-RELEASE; MONONUCLEAR-CELLS; LOCAL INJECTION;
D O I：
10.3390/ijms21249759
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.
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页码：1 / 27
页数：28
相关论文
共 191 条
[1]   Crosstalk between skeletal and neural tissues is critical for skeletal health [J].
Abeynayake, Nethmi ;
Arthur, Agnieszka ;
Gronthos, Stan .
BONE, 2021, 142
[2]   CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture [J].
Alvarez-Viejo, Maria ;
Menendez-Menendez, Yolanda ;
Otero-Hernandez, Jesus .
WORLD JOURNAL OF STEM CELLS, 2015, 7 (02) :470-476
[3]  
Antebi Ben, 2016, Bioengineering-Basel, V3, P6, DOI 10.3390/bioengineering3010006
[4]  
Arthur A., 2013, STEM CELLS BONE TISS, P82
[5]   The Therapeutic Applications of Multipotential Mesenchymal/Stromal Stem Cells in Skeletal Tissue Repair [J].
Arthur, Agnieszka ;
Zannettino, Andrew ;
Gronthos, Stan .
JOURNAL OF CELLULAR PHYSIOLOGY, 2009, 218 (02) :237-245
[6]   Phase I/II Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis [J].
Baba, Shunsuke ;
Yamada, Yoichi ;
Komuro, Akira ;
Yotsui, Yoritaka ;
Umeda, Makoto ;
Shimuzutani, Kimishige ;
Nakamura, Sayaka .
STEM CELLS INTERNATIONAL, 2016, 2016
[7]   Bioactive hydrogels for bone regeneration [J].
Bai, Xin ;
Gao, Mingzhu ;
Syed, Sahla ;
Zhuang, Jerry ;
Xu, Xiaoyang ;
Zhang, Xue-Qing .
BIOACTIVE MATERIALS, 2018, 3 (04) :401-417
[8]   Genetic modification of scAAV-equine-BMP-2 transduced bone-marrow-derived mesenchymal stem cells before and after cryopreservation: An "off-the-shelf" option for fracture repair [J].
Ball, Alyssa N. ;
Phillips, Jennifer N. ;
McIlwraith, C. Wayne ;
Kawcak, Christopher E. ;
Samulski, Richard J. ;
Goodrich, Laurie R. .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2019, 37 (06) :1310-1317
[9]   Hydroxyapatite reinforced inherent RGD containing silk fibroin composite scaffolds: Promising platform for bone tissue engineering [J].
Behera, Sibaram ;
Naskar, Deboki ;
Sapru, Sunaina ;
Bhattacharjee, Promita ;
Dey, Tuli ;
Ghosh, Ananta K. ;
Mandal, Mahitosh ;
Kundu, Subhas C. .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017, 13 (05) :1745-1759
[10]   In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs [J].
Bez, Maxim ;
Sheyn, Dmitriy ;
Tawackoli, Wafa ;
Avalos, Pablo ;
Shapiro, Galina ;
Giaconi, Joseph C. ;
Da, Xiaoyu ;
Ben David, Shiran ;
Gavrity, Jayne ;
Awad, Hani A. ;
Bae, Hyun W. ;
Ley, Eric J. ;
Kremen, Thomas J. ;
Gazit, Zulma ;
Ferrara, Katherine W. ;
Pelled, Gadi ;
Gazit, Dan .
SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (390)
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