Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation

被引：95
作者：
Aparicio, Jesus F. [1 ]
Barreales, Eva G. [1 ]
Payero, Tamara D. [1 ]
Vicente, Claudia M. [2 ]
de Pedro, Antonio [1 ]
Santos-Aberturas, Javier [3 ]
机构：
[1] Univ Leon, Fac Biol, Area Microbiol, E-24071 Leon, Spain
[2] Univ Lorraine, UMR 1128, INRA, Dynam Genomes & Adaptat Microbienne, F-54506 Vandoeuvre Les Nancy, France
[3] John Innes Ctr, Dept Mol Microbiol, Norwich NR4 7UH, Norfolk, England
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2016年 / 100卷 / 01期
关键词：
Antifungal agent; Cheese; Gene regulation; Keratitis; Metabolic engineering; Polyene macrolide; Preservative E-235; Streptomyces; POLYENE MACROLIDE ANTIBIOTICS; STREPTOMYCES-CHATTANOOGENSIS L10; NATAMYCIN PRODUCTION; ANTIFUNGAL ACTIVITY; POSITIVE REGULATOR; AMPHOTERICIN-B; GENE-CLUSTER; PI-FACTOR; ENGINEERED BIOSYNTHESIS; NIKKOMYCIN BIOSYNTHESIS;
D O I：
10.1007/s00253-015-7077-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus Streptomyces, has found application in human therapy, in the food and beverage industries and as pesticide. It displays a broad spectrum of activity, targeting ergosterol but bearing a particular mode of action different to other polyene macrolides. The biosynthesis of this only antifungal agent with a GRAS status has been thoroughly studied, which has permitted the manipulation of producers to engineer the biosynthetic gene clusters in order to generate several analogues. Regulation of its production has been largely unveiled, constituting a model for other polyenes and setting the leads for optimizing the production of these valuable compounds. This review describes and discusses the molecular genetics, uses, mode of action, analogue generation, regulation and strategies for increasing pimaricin production yields.
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页码：61 / 78
页数：18
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