Prognosis of Patients with Metastatic Soft Tissue Sarcoma: Advances in Recent Years

被引：43
作者：
Lochner, Jakob [1 ]
Menge, Franka [1 ]
Vassos, Nikolaos [1 ]
Hohenberger, Peter [1 ]
Kasper, Bernd [1 ]
机构：
[1] Heidelberg Univ, Sarcoma Unit, Mannheim Univ, Med Ctr, Theodor Kutzer Ufer 1-3, DE-68167 Mannheim, Germany
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2020年 / 43卷 / 11期
关键词：
Soft tissue sarcoma; Metastasis; Overall survival; Prognosis; Prognostic factors; PHASE-II; SURVIVAL; CENTERS; GRADE;
D O I：
10.1159/000509519
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: The objective of this study was to investigate the prognosis of patients with metastatic soft tissue sarcomas (STS) and to define prognostic indicators for overall survival (OS). Methods: All patients who were treated at the Sarcoma Unit at the Mannheim University Medical Center between 2010 and 2016 and who developed metastatic disease deriving from a STS were included in this retrospective analysis. OS was investigated using data from clinical records and German registry offices. Clinical and pathological characteristics were recorded and analyzed. Results: A total number of 212 patients developed metastatic disease from STS during that period. Median OS after first documentation of metastatic disease was 24 months (95% CI 21-33). 1-, 2-, and 5-year OS rates were 70.0% (95% CI 64-77), 49.9% (95% CI 43-58), and 24.8% (95% CI 19-33), respectively. In multivariate analysis, significant predictors for mortality appeared to be gender, age, location and size of the primary tumor, histology, and disease-free interval. Conclusion: Being treated in a high-volume STS reference center in Germany, patients with metastatic disease could demonstrate an increased OS compared to former analyses. These data can be used as a benchmark for upcoming studies and highlight that further research on treatment strategies in this rare disease is urgently needed. (C) 2020 S. Karger AG, Basel
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收藏
页码：613 / 619
页数：7
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