Cerebrovascular regulation, exercise, and mild traumatic brain injury

被引:94
作者
Tan, Can Ozan [1 ]
Meehan, William P., III [2 ]
Iverson, Grant L. [3 ,4 ]
Taylor, J. Andrew [1 ]
机构
[1] Harvard Univ, Cardiovasc Res Lab, Spaulding Rehabil Hosp, Dept Phys Med & Rehabil,Med Sch, Cambridge, MA 02138 USA
[2] Harvard Univ, Micheli Ctr Sports Injury Prevent, Boston Childrens Hosp, Div Sports Med,Dept Pediat & Orthoped,Med Sch, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Phys Med & Rehabil, Massachusetts Gen Hosp Sport Concuss Clin, Med Sch,Spaulding Rehabil Hosp,Red Sox Fdn, Cambridge, MA 02138 USA
[4] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA
关键词
CEREBRAL-BLOOD-FLOW; CORTICAL IMPACT INJURY; HEAD-INJURY; TRANSCRANIAL DOPPLER; MYOGENIC MECHANISMS; DYNAMIC EXERCISE; CO2; REACTIVITY; CARBON-DIOXIDE; NITRIC-OXIDE; AUTOREGULATION;
D O I
10.1212/WNL.0000000000000944
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A substantial number of people who sustain a mild traumatic brain injury report persistent symptoms. Most common among these symptoms are headache, dizziness, and cognitive difficulties. One possible contributor to sustained symptoms may be compromised cerebrovascular regulation. In addition to injury-related cerebrovascular dysfunction, it is possible that prolonged rest after mild traumatic brain injury leads to deconditioning that may induce physiologic changes in cerebral blood flow control that contributes to persistent symptoms in some people. There is some evidence that exercise training may reduce symptoms perhaps because it engages an array of cerebrovascular regulatory mechanisms. Unfortunately, there is very little work on the degree of impairment in cerebrovascular control that may exist in patients with mild traumatic brain injury, and there are no published studies on the subacute phase of recovery from this injury. This review aims to integrate the current knowledge of cerebrovascular mechanisms that might underlie persistent symptoms and seeks to synthesize these data in the context of exploring aerobic exercise as a feasible intervention to treat the underlying pathophysiology.
引用
收藏
页码:1665 / 1672
页数:8
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