Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?

被引：53

作者：

Chiricozzi, Andrea ^{[1
,2
]}

Saraceno, Rosita ^{[1
]}

Chimenti, Maria Sole ^{[3
]}

Guttman-Yassky, Emma ^{[4
,5
]}

Krueger, James G. ^{[6
]}

机构：

[1] Univ Roma Tor Vergata, Dept Dermatol, I-00133 Rome, Italy

[2] Rockefeller Univ, Lab Investigat Dermatol, New York, NY 10065 USA

[3] Univ Roma Tor Vergata, Dept Internal Med Rheumatol Allergol & Clin Immun, I-00133 Rome, Italy

[4] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Inst Immunol, New York, NY 10029 USA

[6] Rockefeller Univ, Lab Investigat Dermatol, Milstein Med Res Program, New York, NY 10065 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2014年 / 18卷 / 05期

关键词：

anti-p19; biologics; guselkumab; IL-17; IL-23; IL-23p19; psoriasis; Th17; tildrakizumab; GROWTH-FACTOR-BETA; HUMAN DENDRITIC CELLS; MUCOSAL HOST-DEFENSE; T-CELLS; MONOCLONAL-ANTIBODY; IFN-GAMMA; IN-VITRO; EPIDERMAL HYPERPLASIA; VULGARIS LESIONS; IMMUNE-RESPONSE;

D O I：

10.1517/14728222.2014.889686

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Psoriasis is a chronic inflammatory skin disorder determined by the activation of several immune cells and resident tissue cells. Various cytokines mediate inflammatory signals, including IL-23, which is an important factor involved in the differentiation of T helper (Th17) cells. Areas covered: Increasing evidence suggests that IL-23 is a central cytokine to the pathogenesis of psoriasis. An overview on both experimental and human data will be reported in order to support the hypothesis of a key pathogenic role of IL-23/Th17 axis. Expert opinion: Targeting IL-23 might be a more selective, valid and effective therapeutic approach, which, potentially, may show important advantages in terms of long-term efficacy and safety in the treatment of psoriasis.

引用

页码：513 / 525

页数：13

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