Oxidized LDL and NO synthesis-Biomarkers of endothelial dysfunction and ageing

被引：131

作者：

Gradinaru, Daniela ^{[1
,2
]}

Borsa, Claudia ^{[1
]}

Ionescu, Cristina ^{[1
]}

Prada, Gabriel Ioan ^{[1
,3
]}

机构：

[1] Ana Asian Natl Inst Gerontol & Geriatr, Bucharest 011241, Romania

[2] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest 020956, Romania

[3] Carol Davila Univ Med & Pharm, Fac Med, Dept Geriatr & Gerontol, Bucharest 020021, Romania

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2015年 / 151卷

关键词：

Oxidized LDL; Nitric oxide; Ageing; Biomarker; Endothelial dysfunction; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS MARKERS; C-REACTIVE PROTEIN; ACUTE CORONARY SYNDROME; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; CARDIOVASCULAR-DISEASE; INDEPENDENT PREDICTOR; VASCULAR ENDOTHELIUM; MOLECULAR-MECHANISMS;

D O I：

10.1016/j.mad.2015.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidized LDL (oxLDL) and nitric oxide (NO) exert contradictory actions within the vascular endothelium microenvironment influencing key events in atherogenesis. OxLDL and NO are so far regarded as representative parameters of oxidative stress and endothelial dysfunction, new targets in prevention, diagnosis and therapy of cardiovascular diseases, and also as candidate biomarkers in evaluating the human biological age. The aim of this review is to explore recent literature on molecular mechanisms and pathophysiological relationships between LDL oxidation, NO synthesis and vascular endothelium function/dysfunction in ageing, focusing on the following aspects: (1) the impact of metabolic status on both LDL oxidation and NO synthesis in relation with oxidative stress, (2) the use of oxidized LDL and NO activity as biomarkers in human studies reporting on cardiovascular outcomes, and (3) evidences supporting the importance of oxidized LDL and NO activity as relevant biomarkers in vascular ageing and age-related diseases. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：101 / 113

页数：13

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