TIMP3 checks inflammation

被引：69

作者：

Black, RA ^{[1
]}

机构：

[1] Amgen Inc, Seattle, WA USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 09期

关键词：

D O I：

10.1038/ng0904-934

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mice deficient in the metalloprotease inhibitor TIMP3, which inhibits the tumor-necrosis factor alpha (TNF-alpha)-converting enzyme (TACE, also called ADAM17), have elevated levels of TNF and severe inflammation in the liver. This result confirms the physiological importance of the soluble form of TNF and identifies TIMP3 as a crucial regulator of this inflammatory cytokine.

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收藏

页码：934 / 935

页数：3

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