The nagging question of the function of N-acetylaspartylglutamate

被引：143
作者：
Coyle, JT [1 ]
机构：
[1] HARVARD UNIV, SCH MED, DEPT PSYCHIAT, BELMONT, MA 02178 USA
来源：
NEUROBIOLOGY OF DISEASE | 1997年 / 4卷 / 3-4期
关键词：
D O I：
10.1006/nbdi.1997.0153
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
N-Acetylaspartylglutamate (NAAG) is a neuropeptide found in millimolar concentrations in brain that is localized to subpopulations of glutamatergic, cholinergic, GABAergic, and noradrenergic neuronal systems. NAAG is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders. (C) 1997 Academic Press.
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收藏
页码：231 / 238
页数：8
相关论文
共 68 条
[1]   LOCALIZATION OF N-ACETYLASPARTYLGLUTAMATE-LIKE IMMUNOREACTIVITY IN SELECTED AREAS OF THE RAT-BRAIN [J].
ANDERSON, KJ ;
MONAGHAN, DT ;
CANGRO, CB ;
NAMBOODIRI, MAA ;
NEALE, JH ;
COTMAN, CW .
NEUROSCIENCE LETTERS, 1986, 72 (01) :14-20
[2]   N-ACETYLASPARTYLGLUTAMATE IDENTIFIED IN THE RAT RETINAL GANGLION-CELLS AND THEIR PROJECTIONS IN THE BRAIN [J].
ANDERSON, KJ ;
BORJA, MA ;
COTMAN, CW ;
MOFFETT, JR ;
NAMBOODIRI, MAA ;
NEALE, JH .
BRAIN RESEARCH, 1987, 411 (01) :172-177
[3]   N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE IS EXPRESSED BY NON-MYELINATING SCHWANN-CELLS IN THE PERIPHERAL NERVOUS-SYSTEM [J].
BERGER, UV ;
CARTER, RE ;
MCKEE, M ;
COYLE, JT .
JOURNAL OF NEUROCYTOLOGY, 1995, 24 (02) :99-109
[4]   N-Acetylated alpha-linked acidic dipeptidase may be involved in axon Schwann cell signalling [J].
Berger, UV ;
Schwab, ME .
JOURNAL OF NEUROCYTOLOGY, 1996, 25 (09) :499-512
[5]  
BERNSTEIN J, 1985, J NEUROSCI, V5, P1429
[6]   Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor [J].
Bischofberger, J ;
Schild, D .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (03) :2089-2092
[7]   SELECTIVE IMMUNOCYTOCHEMICAL STAINING OF MITRAL CELLS IN RAT OLFACTORY-BULB WITH AFFINITY PURIFIED ANTIBODIES AGAINST N-ACETYL-ASPARTYL-GLUTAMATE [J].
BLAKELY, RD ;
ORYLAVOLLEE, L ;
GRZANNA, R ;
KOLLER, KJ ;
COYLE, JT .
BRAIN RESEARCH, 1987, 402 (02) :373-378
[8]   HYDROLYSIS OF THE BRAIN DIPEPTIDE N-ACETYL-L-ASPARTYL-L-GLUTAMATE - SUBCELLULAR AND REGIONAL DISTRIBUTION, ONTOGENY, AND THE EFFECT OF LESIONS ON N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE ACTIVITY [J].
BLAKELY, RD ;
ROBINSON, MB ;
THOMPSON, RC ;
COYLE, JT .
JOURNAL OF NEUROCHEMISTRY, 1988, 50 (04) :1200-1209
[9]  
BLAKELY RD, 1988, INT REV NEUROBIOL, V30, P39
[10]  
BLAKELY RD, 1986, J NEUROCHEM, V47, P1013
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