Survivin beyond physiology: Orchestration of multistep carcinogenesis and therapeutic potentials

被引：61
作者：
Athanasoula, Kalliopi Ch. [1 ]
Gogas, Helen [1 ]
Polonifi, Katerina [1 ]
Vaiopoulos, Aristeidis G. [1 ]
Polyzos, Aristidis [1 ]
Mantzourani, Marina [1 ]
机构：
[1] Univ Athens, Sch Med, Dept Med 1, Laiko Gen Hosp, GR-11527 Athens, Greece
来源：
CANCER LETTERS | 2014年 / 347卷 / 02期
关键词：
Survivin; Cancer; Targeted therapy; Anti-apoptotic protein; IAP family; CELL LUNG-CANCER; SEPANTRONIUM BROMIDE YM155; SMALL-MOLECULE SUPPRESSOR; BREAST-CANCER; PHASE-II; COLORECTAL-CANCER; NUCLEAR SURVIVIN; SPLICE VARIANTS; INHIBITS APOPTOSIS; TARGETING SURVIVIN;
D O I：
10.1016/j.canlet.2014.02.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Survivin, a member of the inhibitor of apoptosis protein family, has been associated with protection from cell apoptosis and regulation of mitosis. Survivin exhibits low to undetectable expression in most finally differentiated adult tissues but is abundantly over-expressed in almost all cancers. The aberrant high expression of survivin in cancers is associated with advanced disease, increased rate of tumor recurrence, abbreviated overall survival and resistance to chemo- and radio- therapy. Survivin touches nearly every aspect of cancer and is involved in the initiation, maintenance and development of tumor. Therefore, its significance in cancer dictates the pursuit for anti-survivin cancer therapies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：175 / 182
页数：8
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