A new daidzein derivative from endophytic Streptomyces sp YIM 65408

被引：11

作者：

Yang, Yabin ^{[1
]}

Yang, Xueqiong ^{[1
]}

Zhang, Yong ^{[1
]}

Zhou, Hao ^{[1
]}

Zhang, Jucheng ^{[1
]}

Xu, Lihua ^{[2
]}

Ding, Zhongtao ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China

[2] Yunnan Univ, Yunnan Inst Microbiol, Kunming 650091, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Streptomyces sp; 1-O-methyl-8-hydroxymethyl-daidzein; antioxidant; biotransformation; METABOLITES; GENISTEIN;

D O I：

10.1080/14786419.2012.750317

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new daidzein derivative, 1-O-methyl-8-hydroxymethyl-daidzein (1) was isolated from Streptomyces sp. YIM 65408 in soybean powder containing medium. The structure was elucidated on the basis of extensive 1D and 2D NMR as well as HR-ESI-MS spectroscopic analyses. The radical-scavenging activity and cytotoxicity of compound 1 were also investigated, and 1 was found to be more active than daidzein in the 2,2-diphenyl-1-picrylhydrazyl method with IC50 at 0.60mmol/L, but no cytotoxicity of 1 against HL-60, SMMC-7721, A-549, MCF-7 and SW480 cell lines was shown. The possible biosynthesis pathway from daidzein (2) to compound 1 was proposed.

引用

页码：1727 / 1731

页数：5

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