Synthesis and cytotoxic activity of N-[2-(dimethylamino)ethyl] carboxamide derivatives of benzofuro[2,3-b]quinoline, 6H-quinindoline, indeno[2,1-b] quinoline and [1] benzothieno[2,3-b] quinoline

被引：14
|
作者：
Bu, XY
Deady, LW [1 ]
Denny, WA
机构：
[1] La Trobe Univ, Dept Chem, Bundoora, Vic 3083, Australia
[2] Univ Auckland, Fac Med & Hlth Sci, Auckland Canc Soc, Res Ctr, Auckland 1, New Zealand
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2000年 / 53卷 / 02期
关键词：
antitumour; cytotoxic; synthesis; carboxamides; quinoline;
D O I：
10.1071/CH99166
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The acid precursors of the title compounds were prepared from methyl 2-amino-3-formylbenzoate (3), by Friedlander synthesis with o-methoxy- and o-nitro-phenylacetic acids, phenylpyruvic acid and benzo[b]thiophen-2-one, respectively. Except for the last example, cyclization of an initial 3-arylquinoline derivative was then required to give the tetracycle. Growth inhibition properties of the carboxamides in a series of cancer cell lines were measured for comparison with previous data for an isomeric series. In all cases, the present set were found to be less active.
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收藏
页码：143 / 147
页数：5
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