Diethylpropion and mazindol: An end to the discussion?

被引：3

作者：

Lucchetta, Rosa Camila ^{[1
]}

Riveros, Bruno Salgado ^{[1
]}

Pontarolo, Roberto ^{[1
]}

Radominski, Rosana Bento ^{[2
]}

Otuki, Michel Fleith ^{[3
]}

Fernandez-Llimos, Fernando ^{[4
]}

Correr, Cassyano Januario ^{[1
]}

机构：

[1] Univ Fed Parana UFPR, Pharm Dept, Lab Clin Serv & Evidence Hlth, Curitiba, PR, Brazil

[2] UFPR, Hosp Clin, Serv Endocrinol & Metab, Curitiba, PR, Brazil

[3] Univ Estadual Ponta Grossa UEPG, Dept Pharmaceut Sci, Ponta Grossa, PR, Brazil

[4] Univ Lisbon, Fac Pharm, Dept Social Pharm, Res Inst Med iMed ULisboa, Lisbon, Portugal

来源：

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2017年 / 63卷 / 03期

关键词：

obesity; weight loss; treatment outcome; evidence-based practice; ANTIOBESITY DRUGS; WEIGHT-LOSS; EFFICACY; OBESITY; TRIALS; SAFETY;

D O I：

10.1590/1806-9282.63.03.203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiobesity pharmacotherapy remains the main point of disagreement among both scientists and regulators. This is probably due to small sample sizes, high levels of heterogeneity, and low methodological quality. For many years, Brazil was one of the largest consumers of appetite suppressants worldwide, with evidence of irrational use of this drug class. Therefore, the country was the scene of a debate that divided the Brazilian Health Surveillance Agency (Anvisa-Agencia Nacional de Vigilancia Sanitaria) and medical societies over the maintenance record of diethylpropion, mazindol and fenproporex. In this context, this commentary presents new arguments to contribute to the discussion, as well as recommendations for future studies.

引用

页码：203 / 206

页数：4

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