SENSITIVITY ANALYSIS FOR OSCILLATING DYNAMICAL SYSTEMS

被引:35
作者
Wilkins, A. Katharina [1 ]
Tidor, Bruce [2 ]
White, Jacob [2 ]
Barton, Paul I. [1 ]
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
关键词
periodic system; limit cycle; nonlinear ODEs; boundary value problem; amplitude sensitivity; period sensitivity; phase sensitivity; phase locking condition; DIFFERENTIAL-ALGEBRAIC SYSTEMS; MAMMALIAN CIRCADIAN CLOCK; NUMERICAL-METHODS; PHASE NOISE; MODEL; COMPUTATION;
D O I
10.1137/070707129
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
Boundary value formulations are presented for exact and efficient sensitivity analysis, with respect to model parameters and initial conditions, of different classes of oscillating systems. Methods for the computation of sensitivities of derived quantities of oscillations such as period, amplitude, and different types of phases are first developed for limit-cycle oscillators. In particular, a novel decomposition of the state sensitivities into three parts is proposed to provide an intuitive classification of the influence of parameter changes on period, amplitude, and relative phase. The importance of the choice of time reference, i.e., the phase locking condition, is demonstrated and discussed, and its influence on the sensitivity solution is quantified. The methods are then extended to other classes of oscillatory systems in a general formulation. Numerical techniques are presented to facilitate the solution of the boundary value problem and the computation of different types of sensitivities. Numerical results are verified by demonstrating consistency with finite difference approximations and are superior both in computational efficiency and in numerical precision to existing partial methods.
引用
收藏
页码:2706 / 2732
页数:27
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