Copper-mediated radical alkylarylation of unactivated alkenes with acetonitrile leading to fluorenes and pyrroloindoles

被引：47

作者：

Chu, Xue-Qiang

Xing, Zhen-Hua

Meng, Hua

Xu, Xiao-Ping ^{[1
]}

Ji, Shun-Jun ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2016年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

H BOND FUNCTIONALIZATION; ACTIVATED ALKENES; MICHAEL REACTIONS; FORMING REACTIONS; ALLYLIC ALCOHOLS; RECENT PROGRESS; ALKYL NITRILES; CYCLIZATION; TRIFLUOROMETHYLATION; CONSTRUCTION;

D O I：

10.1039/c5qo00329f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Cu-mediated/catalyzed selective oxidative dual C-H bond cleavage of an arene and alkylnitrile or acetone is reported. This method provides a novel approach to highly functionalized fluorene and pyrroloindole derivatives, which are useful in pharmaceutical and photoelectronic areas. In this reaction, two new C(sp(3))-C(sp(3)) and C(Ar)-C(sp(3)) bonds, a quaternary center and a five-membered ring are simultaneously formed.

引用

页码：165 / 169

页数：5

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