Adjuvant therapy following induction therapy and surgery improves survival in N2-positive non-small cell lung cancer
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作者:
White, Abby A.
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
White, Abby A.
[1
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Lee, Daniel N.
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Lee, Daniel N.
[1
]
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Mazzola, Emanuele
[2
]
Kucukak, Suden
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Kucukak, Suden
[1
]
Polhemus, Emily
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Polhemus, Emily
[1
]
Jaklitsch, Michael T.
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Jaklitsch, Michael T.
[1
]
Mentzer, Steven J.
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Mentzer, Steven J.
[1
]
Wee, Jon O.
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Wee, Jon O.
[1
]
Bueno, Raphael
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Bueno, Raphael
[1
]
Swanson, Scott J.
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Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USABrigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
Swanson, Scott J.
[1
]
机构:
[1] Brigham & Womens Hosp, Div Thorac Surg, 75 Francis St, Boston, MA 02115 USA
[2] Dana Farber Canc Inst, Div Biostat, Dept Data Sci, Boston, MA USA
Background The purpose of this study was to evaluate treatment strategies and factors influencing overall survival (OS) and disease-free survival (DFS) in resectable, non-small cell lung cancer (NSCLC) with mediastinal (N2) lymph node metastasis. Methods All patients undergoing surgery for NSCLC with N2 disease between 2006 and 2016 were included. Treatment approaches included surgery only, neoadjuvant therapy followed by surgery, surgery followed by adjuvant therapy, and neoadjuvant therapy followed by surgery and adjuvant therapy (triple therapy). Patient clinical and pathologic data were retrospectively collected. Results A total of 281 patients were included in the study. In total, 209 patients had neoadjuvant therapy, 47.4% of which went on to received additional adjuvant therapy. The pathologic complete response rate was 12.9%. The treatment strategy which included triple therapy was isolated as a significant contributor to improved OS and DFS. Nodal downstaging (N0) after induction therapy conferred an OS benefit (38.3% vs. 15.6%, p = .03). Patients with single-station N2 disease experienced higher DFS. Video-assisted thoracic surgery (VATS) lobectomy completion rates were higher at the end of the study period compared to the beginning (p < .001). Conclusions Patients who undergo neoadjuvant therapy for N2-positive NSCLC may benefit from additional adjuvant therapy. Single-station N2 disease confers higher DFS. VATS completion rates for lobectomy increase as experience increases.
机构:
Loyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Albain, Kathy S.
Swann, R. Suzanne
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h-index: 0
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Radiat Therapy Oncol Grp, Philadelphia, PA USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Swann, R. Suzanne
Rusch, Valerie W.
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h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, New York, NY 10021 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Rusch, Valerie W.
Turrisi, Andrew T., III
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h-index: 0
机构:
Wayne State Univ, Detroit, MI USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Turrisi, Andrew T., III
Shepherd, Frances A.
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h-index: 0
机构:
Univ Hlth Network, Princess Margaret Hosp Site, Toronto, ON, CanadaLoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Shepherd, Frances A.
Smith, Colum
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h-index: 0
机构:
Tom Baker Canc Clin, Calgary, AB, CanadaLoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Smith, Colum
Chen, Yuhchyau
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h-index: 0
机构:
Univ Rochester, Med Ctr, Rochester, NY 14642 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Chen, Yuhchyau
Livingston, Robert B.
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h-index: 0
机构:
Univ Arizona, Ctr Canc, Tucson, AZ USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Livingston, Robert B.
Feins, Richard H.
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h-index: 0
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Univ N Carolina, Chapel Hill, NC USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Feins, Richard H.
Gandara, David R.
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h-index: 0
机构:
Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Gandara, David R.
Fry, Willard A.
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h-index: 0
机构:
NorthShore Univ Hlth Syst, Evanston Hosp, Evanston, IL USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Fry, Willard A.
Darling, Gail
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hlth Network, Toronto Gen Hosp Site, Toronto, ON, CanadaLoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Bueno, R
Richards, WG
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Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Richards, WG
Swanson, SJ
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Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Swanson, SJ
Jaklitsch, MT
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h-index: 0
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Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Jaklitsch, MT
Lukanich, JM
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Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Lukanich, JM
Mentzer, SJ
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Mentzer, SJ
Sugarbaker, DJ
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
机构:
Loyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Albain, Kathy S.
Swann, R. Suzanne
论文数: 0引用数: 0
h-index: 0
机构:
Radiat Therapy Oncol Grp, Philadelphia, PA USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Swann, R. Suzanne
Rusch, Valerie W.
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, New York, NY 10021 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Rusch, Valerie W.
Turrisi, Andrew T., III
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Detroit, MI USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Turrisi, Andrew T., III
Shepherd, Frances A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hlth Network, Princess Margaret Hosp Site, Toronto, ON, CanadaLoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Shepherd, Frances A.
Smith, Colum
论文数: 0引用数: 0
h-index: 0
机构:
Tom Baker Canc Clin, Calgary, AB, CanadaLoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Smith, Colum
Chen, Yuhchyau
论文数: 0引用数: 0
h-index: 0
机构:
Univ Rochester, Med Ctr, Rochester, NY 14642 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Chen, Yuhchyau
Livingston, Robert B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Ctr Canc, Tucson, AZ USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Livingston, Robert B.
Feins, Richard H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Chapel Hill, NC USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Feins, Richard H.
Gandara, David R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Davis, Ctr Canc, Sacramento, CA 95817 USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Gandara, David R.
Fry, Willard A.
论文数: 0引用数: 0
h-index: 0
机构:
NorthShore Univ Hlth Syst, Evanston Hosp, Evanston, IL USALoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
Fry, Willard A.
Darling, Gail
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hlth Network, Toronto Gen Hosp Site, Toronto, ON, CanadaLoyola Univ Chicago, Stritch Sch Med, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Bueno, R
Richards, WG
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Richards, WG
Swanson, SJ
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Swanson, SJ
Jaklitsch, MT
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Jaklitsch, MT
Lukanich, JM
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Lukanich, JM
Mentzer, SJ
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA
Mentzer, SJ
Sugarbaker, DJ
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USAHarvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Thorac Surg, Boston, MA 02115 USA