Exosomes and Cardiovascular Protection

被引：72

作者：

Davidson, Sean M. ^{[1
]}

Takov, Kaloyan ^{[1
]}

Yellon, Derek M. ^{[1
]}

机构：

[1] Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1E 6HX, England

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2017年 / 31卷 / 01期

关键词：

Exosomes; Microvesicles; Microparticles; Stem cells; Cardioprotection; MICROPARTICLES INDUCE ANGIOGENESIS; EXTRACELLULAR VESICLES; CARDIAC-FUNCTION; PROGENITOR CELLS; MICROVESICLES; MEDIATE; ENHANCE; BLOOD; HEART; TRANSFERRIN;

D O I：

10.1007/s10557-016-6698-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the socalled "paracrine" benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart.

引用

页码：77 / 86

页数：10

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