Enantioselective Linchpin Catalysis by SOMO Catalysis: An Approach to the Asymmetric α-Chlorination of Aldehydes and Terminal Epoxide Formation

被引：153

作者：

Amatore, Muriel ^{[1
]}

Beeson, Teresa D. ^{[1
]}

Brown, Sean P. ^{[1
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 28期

关键词：

epoxidation; enantioselectivity; asymmetric catalysis; organocatalysis; HYDROLYTIC KINETIC RESOLUTION; HALOGENATION; ORGANOCATALYSIS; ACTIVATION; COMPLEXES; OLEFINS; KETONES;

D O I：

10.1002/anie.200901855

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the α-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5121 / 5124

页数：4

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