Bioactive Sambong oil-loaded electrospun cellulose acetate nanofibers: Preparation, characterization, and in-vitro biocompatibility

被引：73

作者：

Ullah, Azeem ^{[1
]}

Saito, Yusuke ^{[1
]}

Ullah, Sana ^{[1
]}

Haider, Md Kaiser ^{[1
]}

Nawaz, Hifza ^{[2
]}

Phan Duy-Nam ^{[3
]}

Kharaghani, Davood ^{[4
]}

Kim, Ick Soo ^{[1
]}

机构：

[1] Shinshu Univ, Inst Fiber Engn IFES, Interdisciplinary Cluster Cutting Edge Res ICCER, Nano Fus Technol Res Grp, Tokida 3-15-1, Ueda 3868567, Japan

[2] Univ Manchester, Dept Mat, Manchester M13 9PL, Lancs, England

[3] Hanoi Univ Sci & Technol, Sch Text Leather & Fash, 1 Dai Co Viet Rd, Hanoi 10000, Vietnam

[4] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Calcified Tissue Biol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 166卷

关键词：

Blumea balsamifera oil; Cellulose acetate; Antibacterial; Antioxidant; Release profile; Biocompatibility; ANTIMICROBIAL ACTIVITY; MECHANICAL-PROPERTIES; CONTROLLED-RELEASE; WOUND DRESSINGS; TOPICAL CARRIER; VOLATILE OIL; FIBER MATS; ATR-FTIR; DRUG; CHITOSAN;

D O I：

10.1016/j.ijbiomac.2020.10.257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blumea balsamifera oil loaded cellulose acetate nanofiber mats were prepared by electrospinning. The inclusion of blumea oil increased the nanofiber diameter. FTIR spectra confirm the addition of blumea oil in the nanofiber mats. The XRD pattern suggests that the inclusion of blumea oil has caused a misalignment in the polymer chains of the cellulose acetate. Thus, a decrease in the tensile strength was observed for the blumea oil loaded nanofibers. The increase in fiber diameter causes a reduction in the porosity of the nanofiber mats. The blumea oil loaded nanofiber mats showed antibacterial efficacy against Escherichia coli and Staphylococcus aureus. The blumea oil showed antioxidant abilities against the DPPH solution. MVTR of the neat and blumea oil loaded nanofiber mats was in the range of 2450 1750 g/m(2)/day, which is adequate for the transport of air and moisture from the wound surface. Blumea oil loaded mats showed good cell viability similar to 92% for NM 3T3 cells in more extended periods of incubation. A biphasic release profile was obtained, and the release followed the first-order kinetics depending upon the highest value of the coefficient of correlation R 2 (88.6%). (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：1009 / 1021

页数：13

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