LC-MS-based holistic metabolic profiling. Problems, limitations, advantages, and future perspectives

被引：93

作者：

Gika, Helen G. ^{[1
]}

Wilson, Ian D. ^{[2
]}

Theodoridis, Georgios A. ^{[3
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem Engn, Thessaloniki 54124, Greece

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Surg & Canc, London, England

[3] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2014年 / 966卷

关键词：

Metabolomics; Metabonomics; Standardisation; Quality control; Mass spectrometry; LIQUID-CHROMATOGRAPHY; DAY REPRODUCIBILITY; SYSTEMS BIOLOGY; RETENTION; IDENTIFICATION;

D O I：

10.1016/j.jchromb.2014.01.054

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The present review aims to critically discuss some of the major problems and limitations of LC-MS based metabolomics as experienced from an analytical chemistry standpoint. Metabolomics offers distinct advantages to a variety of life sciences. Continuous development of the field has been realised due to intensive efforts from a great many scientists from widely divergent backgrounds and research interests as demonstrated by the contents of this special issue. The aim of this commentary is to describe current hindrances to field's progress, (some unique to metabolomics, some common with other omics fields or with conventional targeted bioanalysis) to propose some potential solutions to overcome these constraints and to provide a future perspective for likely developments in the field. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 35 条

[1] Metabolomics: from small molecules to big ideas [J].

Baker, Monya .

NATURE METHODS, 2011, 8 (02) :117-121

[2] Large-scale human metabolomics studies: A strategy for data (pre-) processing and validation [J].

Bijlsma, S ;

Bobeldijk, L ;

Verheij, ER ;

Ramaker, R ;

Kochhar, S ;

Macdonald, IA ;

van Ommen, B ;

Smilde, AK .

ANALYTICAL CHEMISTRY, 2006, 78 (02) :567-574

[3] A study on retention "projection" as a supplementary means for compound identification by liquid chromatography-mass spectrometry capable of predicting retention with different gradients, flow rates, and instruments [J].

Boswell, Paul G. ;

Schellenberg, Jonathan R. ;

Carr, Peter W. ;

Cohen, Jerry D. ;

Hegeman, Adrian D. .

JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (38) :6732-6741

[4] Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Fast and Robust Quantification of Anionic and Aromatic Metabolites [J].

Buescher, Joerg Martin ;

Moco, Sofia ;

Sauer, Uwe ;

Zamboni, Nicola .

ANALYTICAL CHEMISTRY, 2010, 82 (11) :4403-4412

[5]

Corso G, 2010, BIOANALYSIS, V2, P1883, DOI [10.4155/bio.10.149, 10.4155/BIO.10.149]

[6] Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography - Electrospray ionization mass spectrometry [J].

Coulier, Leon ;

Bas, Richard ;

Jespersen, Sonja ;

Verheij, Elwin ;

van der Werf, Mariet J. ;

Hankemeier, Thomas .

ANALYTICAL CHEMISTRY, 2006, 78 (18) :6573-6582

[7] Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction [J].

Creek, Darren J. ;

Jankevics, Andris ;

Breitling, Rainer ;

Watson, David G. ;

Barrett, Michael P. ;

Burgess, Karl E. V. .

ANALYTICAL CHEMISTRY, 2011, 83 (22) :8703-8710

[8] Equating, or Correction for Between-Block Effects with Application to Body Fluid LC-MS and NMR Metabolomics Data Sets [J].

Draisma, Harmen H. M. ;

Reijmers, Theo H. ;

van der Kloet, Frans ;

Bobeldijk-Pastorova, Ivana ;

Spies-Faber, Elly ;

Vogels, Jack T. W. E. ;

Meulman, Jacqueline J. ;

Boomsma, Dorret I. ;

van der Greef, Jan ;

Hankemeier, Thomas .

ANALYTICAL CHEMISTRY, 2010, 82 (03) :1039-1046

[9] Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry [J].

Dunn, Warwick B. ;

Broadhurst, David ;

Begley, Paul ;

Zelena, Eva ;

Francis-McIntyre, Sue ;

Anderson, Nadine ;

Brown, Marie ;

Knowles, Joshau D. ;

Halsall, Antony ;

Haselden, John N. ;

Nicholls, Andrew W. ;

Wilson, Ian D. ;

Kell, Douglas B. ;

Goodacre, Royston .

NATURE PROTOCOLS, 2011, 6 (07) :1060-1083

[10] The metabolomics standards initiative (MSI) [J].

Fiehn, Oliver ;

Robertson, Don ;

Griffin, Jules ;

van der Werf, Mariet ;

Nikolau, Basil ;

Morrison, Norman ;

Sumner, Lloyd W. ;

Goodacre, Roy ;

Hardy, Nigel W. ;

Taylor, Chris ;

Fostel, Jennifer ;

Kristal, Bruce ;

Kaddurah-Daouk, Rima ;

Mendes, Pedro ;

van Ommen, Ben ;

Lindon, John C. ;

Sansone, Susanna-Assunta .

METABOLOMICS, 2007, 3 (03) :175-178

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