Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome

被引：32

作者：

Muniz, Carmen ^{[1
,2
]}

Martin-Martin, Lourdes ^{[1
,2
]}

Lopez, Antonio ^{[1
,2
]}

Sanchez-Gonzalez, Blanca ^{[3
]}

Salar, Antonio ^{[3
]}

Almeida, Julia ^{[1
,2
]}

Sancho, Juan-Manuel ^{[4
]}

Maria Ribera, Jose ^{[4
]}

Heras, Cecilia ^{[5
]}

Javier Penalver, Francisco ^{[6
]}

Gomez, Marta ^{[7
]}

Gonzalez-Barca, Eva ^{[8
]}

Alonso, Natalia ^{[9
]}

Navarro, Belen ^{[10
]}

Olave, Teresa ^{[11
]}

Sala, Francisco ^{[12
]}

Conde, Eulogio ^{[13
]}

Antonio Marquez, Jose ^{[14
]}

Cabezudo, Elena ^{[15
]}

Cladera, Antonia ^{[16
]}

Garcia-Malo, Maria ^{[17
]}

Dolores Caballero, Maria ^{[1
,2
]}

Orfao, Alberto ^{[1
,2
]}

机构：

[1] Univ Salamanca, Dept Med,Inst Invest Biomed Salamanca, Inst Biol Mol & Celular Canc, Consejo Super Invest Cientificas,Univ Hosp, E-37008 Salamanca, Spain

[2] Univ Salamanca, Ctr Invest Canc, Dept Hematol, E-37008 Salamanca, Spain

[3] Hosp del Mar, Dept Hematol, Barcelona, Spain

[4] Univ Autonoma Barcelona, Dept Clin Hematol, Inst Catala Oncol, Hosp Germans Trias & Pujol,Jose Carreras Res Inst, E-08193 Barcelona, Spain

[5] Infanta Leonor Hosp, Dept Hematol, Madrid, Spain

[6] Univ Hosp Fdn Alcorcon, Dept Hematol, Madrid, Spain

[7] Univ Inst Parc Tauli, Dept Hematol, Barcelona, Spain

[8] Univ Barcelona, Dept Hematol, Inst Catala Oncol, Hosp Duran & Reynals,Inst Invest Biomed Bellvitga, Barcelona, Spain

[9] Univ Hosp Santiago, Dept Hematol, Santiago De Compostela, Spain

[10] Univ Hosp Puerta Hierro, Dept Hematol, Madrid, Spain

[11] Clin Univ Hosp, Dept Hematol, Zaragoza, Spain

[12] Hosp Navarra, Dept Hematol, Pamplona, Spain

[13] Univ Cantabria, Dept Hematol, Marques Valdecilla Univ Hosp, Fac Med, E-39005 Santander, Spain

[14] Hosp Basurto, Dept Hematol, Bilbao, Spain

[15] Sant Joan De Deu Hosp, Dept Hematol, Manresa, Spain

[16] Hosp Son Llatzer, Dept Hematol, Mallorca, Spain

[17] Vega Baja Hosp, Dept Hematol, Alicante, Spain

来源：

BLOOD | 2014年 / 123卷 / 12期

关键词：

CENTRAL-NERVOUS-SYSTEM; B-CELL LYMPHOMA; FLOW-CYTOMETRY; LEPTOMENINGEAL DISEASE; CLINICAL-SIGNIFICANCE; BURKITTS-LYMPHOMA; SOLUBLE CD27; HIGH-RISK; CSF; IDENTIFICATION;

D O I：

10.1182/blood-2013-11-537993

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Flow cytometry (FCM) is more sensitive than conventional cytology for detection of occult leptomeningeal lymphoma; however, some FCM-negative patients show central nervous system (CNS) recurrence. Here, we evaluated the cerebrospinal fluid (CSF) levels of 13 B-cell-associated markers and their contribution to the diagnosis of CNS lymphoma in 91 diffuse large B-cell lymphomas (DLBCL) and 22 Burkitt lymphomas (BLs). From all markers tested, CD19 was the most informative. Thus, higher soluble CD19(sCD19) levels were associated with a greater frequency of neurological symptoms in DLBCL and BL and with parenchymal CNS lymphoma in DLBCL; sCD19 emerged as a powerful predictor of event-free and overall survival in DLBCL and BL, particularly when combined with FCM detection of CNS disease. These results support the utility of combined FCM detection of lymphoma cells and assessment of sCD19 levels in CSF, for more accurate identification of CNS disease in DLBCL and BL patients.

引用

页码：1864 / 1869

页数：6

共 24 条

[11] Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies [J].

Kersten, MJ ;

Evers, LM ;

Dellemijn, PLI ;

Portegies, P ;

Hintzen, RQ ;

vanLier, RAW ;

vondemBorne, AEGK ;

vanOers, RHJ .

BLOOD, 1996, 87 (05) :1985-1989

[12] Increased levels of CSF soluble CD27 in patients with primary central nervous system lymphoma [J].

Murase, S ;

Saio, M ;

Takenaka, K ;

Shinoda, J ;

Nishimura, Y ;

Sakai, N ;

Takami, T .

CANCER LETTERS, 1998, 132 (1-2) :181-186

[13]

NADLER LM, 1983, J IMMUNOL, V131, P244

[14] Role of CD21 antigen in diffuse large B-cell lymphoma and its clinical significance [J].

Otsuka, M ;

Yakushijin, Y ;

Hamada, M ;

Hato, T ;

Yasukawa, M ;

Fujita, S .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 127 (04) :416-424

[15] Human Peripheral Blood B-Cell Compartments: A Crossroad in B-Cell Traffic [J].

Perez-Andres, M. ;

Paiva, B. ;

Nieto, W. G. ;

Caraux, A. ;

Schmitz, A. ;

Almeida, J. ;

Vogt, R. F., Jr. ;

Marti, G. E. ;

Rawstron, A. C. ;

Van Zelm, M. C. ;

Van Dongen, J. J. M. ;

Johnsen, H. E. ;

Klein, B. ;

Orfao, A. .

CYTOMETRY PART B-CLINICAL CYTOMETRY, 2010, 78B :S47-S60

[16] CD24, a glycosylphosphatidylinositol-anchored molecule, is transiently expressed during the development of human central nervous system and is a marker of human neural cell lineage tumors [J].

Poncet, C ;

Frances, V ;

Gristina, R ;

Scheiner, C ;

Pellissier, JF ;

FigarellaBranger, D .

ACTA NEUROPATHOLOGICA, 1996, 91 (04) :400-408

[17] Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders:: analysis of a series of 432 patients [J].

Quijano, Sandra ;

Lopez, Antonio ;

Rasillo, Ana ;

Barrena, Susana ;

Luz Sanchez, Maria ;

Flores, Juan ;

Fernandez, Carlos ;

Maria Sayagues, Jose ;

Salvador Osuna, Carlos ;

Fernandez, Nuria ;

Gonzalez, Marcos ;

Giraldo, Pilar ;

Giralt, Manuel ;

Carmen Perez, Maria ;

Manuel Martin-Antoran, Jose ;

Gutierrez, Oliver ;

Perdiguer, Luis ;

Diaz Mediavilla, Joaquin ;

Gonzalez Silva, Manuel ;

Asensio del Rio, Agustin ;

Cervero, Carlos ;

Luis Guerra, Jose ;

Butron, Rosario ;

del Carmen Garcia, Maria ;

Almeida, Julia ;

Orfao, Alberto .

BLOOD, 2008, 111 (10) :5130-5141

[18] Identification of Leptomeningeal Disease in Aggressive B-Cell Non-Hodgkin's Lymphoma: Improved Sensitivity of Flow Cytometry [J].

Quijano, Sandra ;

Lopez, Antonio ;

Sancho, Juan Manuel ;

Panizo, Carlos ;

Deben, Guillermo ;

Castilla, Cristina ;

Garcia-Vela, Jose Antonio ;

Salar, Antonio ;

Alonso-Vence, Natalia ;

Gonzalez-Barca, Eva ;

Penalver, Francisco Javier ;

Plaza-Villa, Josefa ;

Morado, Marta ;

Garcia-Marco, Jose ;

Arias, Jesus ;

Briones, Javier ;

Ferrer, Secundino ;

Capote, Javier ;

Nicolas, Concepcion ;

Orfao, Alberto .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (09) :1462-1469

[19] Three or more routes for leukocyte migration into the central nervous system [J].

Ransohoff, RM ;

Kivisäkk, P ;

Kidd, G .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (07) :569-581

[20] Protein biomarker identification in the CSF of patients with CNS lymphoma [J].

Roy, Sushmita ;

Josephson, S. Andrew ;

Fridlyand, Jane ;

Karch, Jon ;

Kadoch, Cigall ;

Karrim, Juliana ;

Damon, Lloyd ;

Treseler, Patrick ;

Kunwar, Sandeep ;

Shuman, Marc A. ;

Jones, Ted ;

Becker, Christopher H. ;

Schulman, Howard ;

Rubenstein, James L. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (01) :96-105

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