Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome

被引：32

作者：

Muniz, Carmen ^{[1
,2
]}

Martin-Martin, Lourdes ^{[1
,2
]}

Lopez, Antonio ^{[1
,2
]}

Sanchez-Gonzalez, Blanca ^{[3
]}

Salar, Antonio ^{[3
]}

Almeida, Julia ^{[1
,2
]}

Sancho, Juan-Manuel ^{[4
]}

Maria Ribera, Jose ^{[4
]}

Heras, Cecilia ^{[5
]}

Javier Penalver, Francisco ^{[6
]}

Gomez, Marta ^{[7
]}

Gonzalez-Barca, Eva ^{[8
]}

Alonso, Natalia ^{[9
]}

Navarro, Belen ^{[10
]}

Olave, Teresa ^{[11
]}

Sala, Francisco ^{[12
]}

Conde, Eulogio ^{[13
]}

Antonio Marquez, Jose ^{[14
]}

Cabezudo, Elena ^{[15
]}

Cladera, Antonia ^{[16
]}

Garcia-Malo, Maria ^{[17
]}

Dolores Caballero, Maria ^{[1
,2
]}

Orfao, Alberto ^{[1
,2
]}

机构：

[1] Univ Salamanca, Dept Med,Inst Invest Biomed Salamanca, Inst Biol Mol & Celular Canc, Consejo Super Invest Cientificas,Univ Hosp, E-37008 Salamanca, Spain

[2] Univ Salamanca, Ctr Invest Canc, Dept Hematol, E-37008 Salamanca, Spain

[3] Hosp del Mar, Dept Hematol, Barcelona, Spain

[4] Univ Autonoma Barcelona, Dept Clin Hematol, Inst Catala Oncol, Hosp Germans Trias & Pujol,Jose Carreras Res Inst, E-08193 Barcelona, Spain

[5] Infanta Leonor Hosp, Dept Hematol, Madrid, Spain

[6] Univ Hosp Fdn Alcorcon, Dept Hematol, Madrid, Spain

[7] Univ Inst Parc Tauli, Dept Hematol, Barcelona, Spain

[8] Univ Barcelona, Dept Hematol, Inst Catala Oncol, Hosp Duran & Reynals,Inst Invest Biomed Bellvitga, Barcelona, Spain

[9] Univ Hosp Santiago, Dept Hematol, Santiago De Compostela, Spain

[10] Univ Hosp Puerta Hierro, Dept Hematol, Madrid, Spain

[11] Clin Univ Hosp, Dept Hematol, Zaragoza, Spain

[12] Hosp Navarra, Dept Hematol, Pamplona, Spain

[13] Univ Cantabria, Dept Hematol, Marques Valdecilla Univ Hosp, Fac Med, E-39005 Santander, Spain

[14] Hosp Basurto, Dept Hematol, Bilbao, Spain

[15] Sant Joan De Deu Hosp, Dept Hematol, Manresa, Spain

[16] Hosp Son Llatzer, Dept Hematol, Mallorca, Spain

[17] Vega Baja Hosp, Dept Hematol, Alicante, Spain

来源：

BLOOD | 2014年 / 123卷 / 12期

关键词：

CENTRAL-NERVOUS-SYSTEM; B-CELL LYMPHOMA; FLOW-CYTOMETRY; LEPTOMENINGEAL DISEASE; CLINICAL-SIGNIFICANCE; BURKITTS-LYMPHOMA; SOLUBLE CD27; HIGH-RISK; CSF; IDENTIFICATION;

D O I：

10.1182/blood-2013-11-537993

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Flow cytometry (FCM) is more sensitive than conventional cytology for detection of occult leptomeningeal lymphoma; however, some FCM-negative patients show central nervous system (CNS) recurrence. Here, we evaluated the cerebrospinal fluid (CSF) levels of 13 B-cell-associated markers and their contribution to the diagnosis of CNS lymphoma in 91 diffuse large B-cell lymphomas (DLBCL) and 22 Burkitt lymphomas (BLs). From all markers tested, CD19 was the most informative. Thus, higher soluble CD19(sCD19) levels were associated with a greater frequency of neurological symptoms in DLBCL and BL and with parenchymal CNS lymphoma in DLBCL; sCD19 emerged as a powerful predictor of event-free and overall survival in DLBCL and BL, particularly when combined with FCM detection of CNS disease. These results support the utility of combined FCM detection of lymphoma cells and assessment of sCD19 levels in CSF, for more accurate identification of CNS disease in DLBCL and BL patients.

引用

页码：1864 / 1869

页数：6

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