Hemorrhagic Bullous Lichen Sclerosus: A Case Report

被引:8
作者
Khatib, Jude [1 ]
Wargo, Jeffrey J. [2 ]
Krishnamurthy, Smita [2 ,3 ,4 ]
Travers, Jeffrey B. [1 ,2 ,3 ]
机构
[1] Wright State Univ, Boonshoft Sch Med, Dept Pharmacol & Toxicol, Dayton, OH 45435 USA
[2] Wright State Univ, Boonshoft Sch Med, Dept Dermatol, Dayton, OH 45435 USA
[3] Wright State Univ, Boonshoft Sch Med, Dept Pathol, Dayton, OH 45435 USA
[4] Dayton VA Med Ctr, Dayton, OH USA
关键词
Administration; Topical; Blister; Lichen Sclerosus et Atrophicus; Skin Abnormalities; ATROPHICUS;
D O I
10.12659/AJCR.919353
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Rare disease Background: Lichen sclerosus (LS) is a chronic autoimmune dermatosis characterized by white, sclerotic, atrophic plaques. Classic LS commonly occurs in the anogenital region, while extragenital lichen sclerosis typically occurs on the trunk and proximal extremities. Bullous lichen sclerosus is a rare variant that can occur in both genital and extragenital LS. Flaccid bullae can form, which may become hemorrhagic and produce a characteristic appearance clinically. Case Report: In this report, we describe the case of a 63-year-old female patient who presented for evaluation of a rapidly growing, erythematous, scaly growth on her back/shoulder that was biopsied and found to be hemorrhagic bullous LS. We will discuss the clinical and histologic features of this case as well as treatment of bullous LS, which in this case was a topical high-potency corticosteroid. Conclusions: Bullous LS has been poorly studied due to the rarity of the condition, with limited investigation of the clinical and histopathologic characteristics of bullous LS and the available treatment options. Although rare, extragenital LS with hemorrhagic bullous features is an important variant of LS that should be considered to ensure appropriate diagnosis and treatment.
引用
收藏
页码:1 / 4
页数:4
相关论文
共 8 条
[1]   Characterization of IgG autoantibodies to extracellular matrix protein 1 in lichen sclerosus [J].
Chan, I ;
Oyama, N ;
Neill, SM ;
Wojnarowska, F ;
Black, MM ;
McGrath, JA .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2004, 29 (05) :499-504
[2]   The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease A Case-Control Study [J].
Cooper, Susan M. ;
Ali, Iaisha ;
Baldo, Maha ;
Wojnarowska, Fenella .
ARCHIVES OF DERMATOLOGY, 2008, 144 (11) :1432-1435
[3]  
Goldstein Andrew T, 2011, J Am Acad Dermatol, V64, pe99, DOI 10.1016/j.jaad.2010.06.011
[4]   British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018 [J].
Lewis, F. M. ;
Tatnall, F. M. ;
Velangi, S. S. ;
Bunker, C. B. ;
Kumar, A. ;
Brackenbury, F. ;
Mustapa, M. F. Mohd ;
Exton, L. S. .
BRITISH JOURNAL OF DERMATOLOGY, 2018, 178 (04) :839-853
[5]   Lichen sclerosus et atrophicus (hallopeau) and related cutaneous atrophies [J].
Nomland, R .
ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY, 1930, 21 (04) :575-594
[6]   Lichen sclerosus [J].
Powell, JJ ;
Wojnarowska, F .
LANCET, 1999, 353 (9166) :1777-1783
[7]   Extragenital bullous lichen sclerosus [J].
Sauder, Maxwell B. ;
Linzon-Smith, Jaclyn ;
Beecker, Jennifer .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 71 (05) :981-984
[8]   LICHEN SCLEROSUS ET ATROPHICUS AND AUTOIMMUNITY - A STUDY OF 350 WOMEN [J].
THOMAS, RHM ;
RIDLEY, CM ;
MCGIBBON, DH ;
BLACK, MM .
BRITISH JOURNAL OF DERMATOLOGY, 1988, 118 (01) :41-46