Telomere length maintenance in stem cell populations

被引：22

作者：

Allen, Nicholas D. ^{[2
]}

Baird, Duncan M. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Cardiff CF14 4XN, S Glam, Wales

[2] Cardiff Univ, Sch Biosci, Cardiff CF10 3, S Glam, Wales

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 04期

基金：

英国医学研究理事会;

关键词：

Telomere; Telomerase; Senescence; Genome stability; Stem cell; MARROW FAILURE SYNDROMES; CD8(+) T-CELLS; DYSKERATOSIS-CONGENITA; SELF-RENEWAL; PROGENITOR PROLIFERATION; EPIGENETIC REGULATION; HEMATOPOIETIC-CELLS; LONGEST TELOMERES; MAMMALIAN-CELLS; SENESCENT CELLS;

D O I：

10.1016/j.bbadis.2009.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The maintenance of telomere length is essential for upholding the integrity of the genome. There is good evidence to suggest that telomere length maintenance in stem cell populations is important to facilitate the cell division required for tissue homeostasis. This is balanced against the requirement in long lived species for proliferative life span barriers for turnout suppression; the gradual erosion of telomeres provides one such barrier. The dynamics of telomeres in stem cell populations may thus be crucial in the balance between turnout suppression and tissue homeostasis. Here we briefly discuss our current understanding of telomere dynamics in stem cell populations, and provide some data to indicate that telomeres in human embryonic stem cells may be more stable and less prone to large-scale stochastic telomeric deletion. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：324 / 328

页数：5

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