Vaccine Evolution and Its Application to Fight Modern Threats

被引：31

作者：

Andreano, Emanuele ^{[1
,2
,3
]}

D'Oro, Ugo ^{[2
]}

Rappuoli, Rino ^{[2
,3
,4
]}

Finco, Oretta ^{[2
]}

机构：

[1] Univ Siena, Dept Life Sci, Siena, Italy

[2] GlaxoSmithKline, Siena, Italy

[3] Toscana Life Sci, vAMRes Lab, Siena, Italy

[4] Imperial Coll, Fac Med, London, England

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

欧洲研究理事会;

关键词：

vaccines; infectious diseases; antimicrobial resistance (AMR); vaccine development; vaccinology; MONOCLONAL-ANTIBODY; 1918; INFLUENZA; B-CELLS; HIV; IDENTIFICATION; RESISTANCE; LESSONS; DESIGN;

D O I：

10.3389/fimmu.2019.01722

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Before the development of the first vaccine, infectious diseases were a major cause of death around the globe with life expectancy estimated to be <50 years. Three measures have helped to drastically reduce the burden of infectious diseases but only vaccines have proven to be able to eradicate infectious agents. Herein, we describe new methodologies that have paved the way for what is currently known as modern vaccinology and the use of vaccines to tackle antimicrobial resistance, the biggest global threat of our time.

引用

页数：5

共 46 条

[1] Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens [J].

Abbott, Robert K. ;

Lee, Jeong Hyun ;

Menis, Sergey ;

Skog, Patrick ;

Rossi, Meghan ;

Ota, Takayuki ;

Kulp, Daniel W. ;

Bhullar, Deepika ;

Kalyuzhniy, Oleksandr ;

Havenar-Daughton, Colin ;

Schief, William R. ;

Nemazee, David ;

Crotty, Shane .

IMMUNITY, 2018, 48 (01) :133-+

[2]

ABRAHAM EP, 1988, REV INFECT DIS, V10, P677

[3]

[Anonymous], 2000, WHO REPORT GLOBAL SU

[4] The World Health Organization and global smallpox eradication [J].

Bhattacharya, S. .

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 2008, 62 (10) :909-912

[5] Antimicrobial resistance and the role of vaccines SPECIAL FEATURE: INTRODUCTION [J].

Bloom, David E. ;

Black, Steven ;

Salisbury, David ;

Rappuoli, Rino .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (51) :12868-12871

[6] Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies [J].

Briney, Bryan ;

Sok, Devin ;

Jardine, Joseph G. ;

Kulp, Daniel W. ;

Skog, Patrick ;

Menis, Sergey ;

Jacak, Ronald ;

Kalyuzhniy, Oleksandr ;

de Val, Natalia ;

Sesterhenn, Fabian ;

Le, Khoa M. ;

Ramos, Alejandra ;

Jones, Meaghan ;

Saye-Francisco, Karen L. ;

Blane, Tanya R. ;

Spencer, Skye ;

Georgeson, Erik ;

Hu, Xiaozhen ;

Ozorowski, Gabriel ;

Adachi, Yumiko ;

Kubitz, Michael ;

Sarkar, Anita ;

Wilson, Ian A. ;

Ward, Andrew B. ;

Nemazee, David ;

Burton, Dennis R. ;

Schief, William R. .

CELL, 2016, 166 (06) :1459-+

[7] Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection [J].

Cohen, Yehuda Z. ;

Caskey, Marina .

CURRENT OPINION IN HIV AND AIDS, 2018, 13 (04) :366-373

[8]

Fenner F., 1988, Smallpox and its eradication

[9] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD [J].

FLEISCHMANN, RD ;

ADAMS, MD ;

WHITE, O ;

CLAYTON, RA ;

KIRKNESS, EF ;

KERLAVAGE, AR ;

BULT, CJ ;

TOMB, JF ;

DOUGHERTY, BA ;

MERRICK, JM ;

MCKENNEY, K ;

SUTTON, G ;

FITZHUGH, W ;

FIELDS, C ;

GOCAYNE, JD ;

SCOTT, J ;

SHIRLEY, R ;

LIU, LI ;

GLODEK, A ;

KELLEY, JM ;

WEIDMAN, JF ;

PHILLIPS, CA ;

SPRIGGS, T ;

HEDBLOM, E ;

COTTON, MD ;

UTTERBACK, TR ;

HANNA, MC ;

NGUYEN, DT ;

SAUDEK, DM ;

BRANDON, RC ;

FINE, LD ;

FRITCHMAN, JL ;

FUHRMANN, JL ;

GEOGHAGEN, NSM ;

GNEHM, CL ;

MCDONALD, LA ;

SMALL, KV ;

FRASER, CM ;

SMITH, HO ;

VENTER, JC .

SCIENCE, 1995, 269 (5223) :496-512

[10]

Fleming A, 1929, BRIT J EXP PATHOL, V10, P226

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