Vaccine Evolution and Its Application to Fight Modern Threats

被引：29
作者：
Andreano, Emanuele [1 ,2 ,3 ]
D'Oro, Ugo [2 ]
Rappuoli, Rino [2 ,3 ,4 ]
Finco, Oretta [2 ]
机构：
[1] Univ Siena, Dept Life Sci, Siena, Italy
[2] GlaxoSmithKline, Siena, Italy
[3] Toscana Life Sci, vAMRes Lab, Siena, Italy
[4] Imperial Coll, Fac Med, London, England
来源：
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
基金：
欧洲研究理事会;
关键词：
vaccines; infectious diseases; antimicrobial resistance (AMR); vaccine development; vaccinology; MONOCLONAL-ANTIBODY; 1918; INFLUENZA; B-CELLS; HIV; IDENTIFICATION; RESISTANCE; LESSONS; DESIGN;
D O I：
10.3389/fimmu.2019.01722
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Before the development of the first vaccine, infectious diseases were a major cause of death around the globe with life expectancy estimated to be <50 years. Three measures have helped to drastically reduce the burden of infectious diseases but only vaccines have proven to be able to eradicate infectious agents. Herein, we describe new methodologies that have paved the way for what is currently known as modern vaccinology and the use of vaccines to tackle antimicrobial resistance, the biggest global threat of our time.
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页数：5
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