Latest update on the Ro/SS-A autoantibody system

被引:183
作者
Schulte-Pelkum, J. [1 ]
Fritzler, M. [2 ]
Mahler, M. [1 ]
机构
[1] Dr Fooke Lab GmbH, Neuss, Germany
[2] Univ Calgary, Fac Med, Calgary, AB, Canada
关键词
Ro52; Ro60 (SS-A); Jo-1; Recombinant antigens; CDC; Polymyositis; Systemic sclerosis; ANTINUCLEAR ANTIBODIES; LUPUS-ERYTHEMATOSUS; SS-A/RO; INDIRECT IMMUNOFLUORESCENCE; SJOGRENS-SYNDROME; RO AUTOANTIGEN; REFERENCE SERA; HEP-2; CELLS; ANTIGEN; AUTOIMMUNITY;
D O I
10.1016/j.autrev.2009.02.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anti-SS-A (Ro52/Ro60) autoantibodies have been described as serological marker for Sjogren's syndrome but are also found in patients with other systemic autoimmune diseases. Historically, these autoantibodies were considered as a uniform autoantibody-system. However, recent studies provided evidence that Ro60 and Ro52 are not part of a stable macromolecular complex and that anti-Ro52 and anti-Ro60 (SS-A) antibodies have different clinical associations. The prevalence of anti-Ro52 in systemic sclerosis and myositis is significantly higher than anti-Ro60 (SS-A) and isolated anti-Ro52 can be found in up to 37% of myositis patients, often correlated with anti-Jo-1 reactivity (p = 0.0002). Furthermore, recent developments have made significant improvements in the quality of recombinant Ro60 showing excellent performance in Ro60 (SS-A) ELISA (Dr. Fooke Laboratorien). Of note, single reactivity to either Ro52 or Ro60 (SS-A) can be missed when measured with a classical SS-A ELISA based on a mixture of both antigens. Approximately 20% of anti-Ro52 or Ro60 (SS-A) positive samples may remain undetected using a mixture of both antigens. Moreover, the international reference sera from the Centers for Disease Control and Prevention (CDC 2, 3, 7, 10) were further characterized. It was concluded that Ro60 (SS-A) and Ro52 represent two distinct autoantibody systems and that separate detection is desirable in a clinical diagnostic setting. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:632 / 637
页数:6
相关论文
共 40 条
[1]   ANTIBODIES TO CELLULAR ANTIGENS IN SJOGRENS SYNDROME [J].
ALSPAUGH, MA ;
TAN, EM .
JOURNAL OF CLINICAL INVESTIGATION, 1975, 55 (05) :1067-1073
[2]   PRECIPITATING AUTO-ANTIBODIES IN CONNECTIVE TISSUE DISEASES [J].
ANDERSON, JR ;
BUCHANAN, WW ;
BECK, JS ;
GRAY, KG ;
MCELHINNEY, AJ .
ANNALS OF THE RHEUMATIC DISEASES, 1962, 21 (04) :360-+
[3]   Development of autoantibodies before the clinical onset of systemic lupus erythematosus [J].
Arbuckle, MR ;
McClain, MT ;
Rubertone, MV ;
Scofield, RH ;
Dennis, GJ ;
James, JA ;
Harley, JB .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (16) :1526-1533
[4]   RNA chaperone activity of protein components of human Ro RNPs [J].
Belisova, A ;
Semrad, K ;
Mayer, O ;
Kocian, G ;
Waigmann, E ;
Schroeder, R ;
Steiner, G .
RNA, 2005, 11 (07) :1084-1094
[5]   ISOLATION AND CHARACTERIZATION OF A CDNA CLONE ENCODING THE 60-KD COMPONENT OF THE HUMAN SS-A/RO RIBONUCLEOPROTEIN AUTO-ANTIGEN [J].
BENCHETRIT, E ;
GANDY, BJ ;
TAN, EM ;
SULLIVAN, KF .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) :1284-1292
[6]  
Bläss S, 2001, ARTHRITIS RHEUM, V44, P761
[7]   Detection of anti-SSA antibodies by indirect immunofluorescence [J].
Bossuyt, X ;
Frans, J ;
Hendrickx, A ;
Godefridis, G ;
Westhovens, R ;
Mariën, G .
CLINICAL CHEMISTRY, 2004, 50 (12) :2361-2369
[8]   Autoantibody profiles in the sera of European patients with myositis [J].
Brouwer, R ;
Hengstman, GJD ;
Egberts, WV ;
Ehrfeld, H ;
Bozic, B ;
Ghirardello, A ;
Grondal, G ;
Hietarinta, M ;
Isenberg, D ;
Kalden, JR ;
Lundberg, I ;
Moutsopoulos, H ;
Roux-Lombard, P ;
Vencovsky, J ;
Wikman, A ;
Seelig, HP ;
van Engelen, BGM ;
van Venrooij, WJ .
ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (02) :116-123
[9]   AutoAbSC.Org - Autoantibody standardization committee in 2006 [J].
Chan, Edward K. L. ;
Fritzler, Marvin J. ;
Wiik, Allan ;
Andrade, Luis E. C. ;
Reeves, Westley H. ;
Tincani, Angela ;
Meroni, Pier Luigi .
AUTOIMMUNITY REVIEWS, 2007, 6 (08) :577-580
[10]  
CHAN EKL, 1992, RHEUM DIS CLIN N AM, V18, P551