Structure, Function and Regulation of the Plasma Membrane Calcium Pump in Health and Disease

被引：17
|
作者：
Krebs, Joachim [1 ]
机构：
[1] Max Planck Inst MPI Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期
关键词：
plasma membrane calcium pump; PMCA; calmodulin; spliced isoforms; microdomains; CALMODULIN-BINDING DOMAIN; ATPASE ISOFORM 3; CA2+ PUMP; CA-2+ PUMP; RAT-BRAIN; CA-2+-TRANSPORTING ATPASE; ADENOSINE-TRIPHOSPHATASE; ERYTHROCYTE-MEMBRANE; MOLECULAR-CLONING; POINT MUTATIONS;
D O I：
10.3390/ijms23031027
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, I summarize the present knowledge of the structural and functional properties of the mammalian plasma membrane calcium pump (PMCA). It is outlined how the cellular expression of the different spliced isoforms of the four genes are regulated under normal and pathological conditions.
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页数：16
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