A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy

被引：63

作者：

Chen, Guoqin ^{[1
,2
]}

Li, Jinliang ^{[1
,3
]}

Cai, Yanbin ^{[4
]}

Zhan, Jie ^{[4
]}

Gao, Jie ^{[5
]}

Song, Mingcai ^{[1
,2
]}

Shi, Yang ^{[4
]}

Yang, Zhimou ^{[4
]}

机构：

[1] Panyu Cent Hosp, Dept Cardiol, Guangzhou 511400, Guangdong, Peoples R China

[2] Cardiovasc Dis Inst Panyu Dist, Guangzhou 511400, Guangdong, Peoples R China

[3] Guangzhou Univ Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[4] Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China

[5] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

IN-VITRO; MICELLES ENHANCE; DELIVERY; NANOPARTICLES; DOXORUBICIN; LIPOSOMES; CHITOSAN; NANOFIBERS; INJECTION; BOOST;

D O I：

10.1038/srep44210

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Curcumin (Cur), a phenolic anti-oxidant compound obtained from Curcuma longa plant, possesses a variety of therapeutic properties. However, it is suffered from its low water solubility and low bioavailability property, which seriously restricts its clinical application. In this study, we developed a glycyrrhetinic acid (GA) modified curcumin supramolecular pro-gelator (GA-Cur) and a control compound Nap-Cur by replacing GA with the naphthylacetic acid (Nap). Both compounds showed good water solubility and could form supramolecular gels by disulfide bond reduction triggered by glutathione (GSH) in vitro. Both formed gels could sustainedly release Cur in buffer solutions. We also investigated the cytotoxicity of pro-gelators to HepG2 cells by a MTT assay and determined the cellular uptake behaviours of them by fluorescence microscopy and LC-MS. Due to the over expression of GA receptor in liver cancer cells, our pro-gelator of GA-Cur showed an enhanced cellular uptake and better inhibition capacity to liver tumor cells than Nap-Cur. Therefore, the GA-Cur could significantly inhibit HepG2 cell growth. Our study provides a novel nanomaterial for liver tumor chemotherapy.

引用

页数：8

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