Virulence-Associated Enzymes of Cryptococcus neoformans

被引：103

作者：

Almeida, Fausto ^{[1
,2
]}

Wolf, Julie M. ^{[1
]}

Casadevall, Arturo ^{[1
,3
]}

机构：

[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cellular & Mol Biol, Sao Paulo, Brazil

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

来源：

EUKARYOTIC CELL | 2015年 / 14卷 / 12期

关键词：

EXTRACELLULAR PROTEINASE ACTIVITY; CAPSULE-ASSOCIATED GENE; CELL-WALL INTEGRITY; FUNGAL PATHOGEN; SUPEROXIDE-DISMUTASE; AMPHOTERICIN-B; PHOSPHOLIPASE-C; IN-VITRO; 6-PHOSPHOGLUCONATE DEHYDROGENASE; PARACOCCIDIOIDES-BRASILIENSIS;

D O I：

10.1128/EC.00103-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or activity can significantly alter the infection process, and enzyme expression profiles can be a hallmark of disease. Hence, enzymes are worthy targets for better understanding pathogenesis and identifying new options for combatting fungal infections. Advances in genomics, proteomics, transcriptomics, and mass spectrometry have enabled the identification and characterization of new fungal enzymes. This review focuses on recent developments in the virulence-associated enzymes from Cryptococcus neoformans. The enzymatic suite of C. neoformans has evolved for environmental survival, but several of these enzymes play a dual role in colonizing the mammalian host. We also discuss new therapeutic and diagnostic strategies that could be based on the underlying enzymology.

引用

页码：1173 / 1185

页数：13

共 202 条

[1] Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans [J].

Akhter, S ;

McDade, HC ;

Gorlach, JM ;

Heinrich, G ;

Cox, GM ;

Perfect, JR .

INFECTION AND IMMUNITY, 2003, 71 (10) :5794-5802

[2] Adenylyl cyclase functions downstream of the Gα protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans [J].

Alspaugh, JA ;

Pukkila-Worley, R ;

Harashima, T ;

Cavallo, LM ;

Funnell, D ;

Cox, GM ;

Perfect, JR ;

Kronstad, JW ;

Heitman, J .

EUKARYOTIC CELL, 2002, 1 (01) :75-84

[3] The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes [J].

Alvarez, Mauricio ;

Burn, Tamika ;

Luo, Yong ;

Pirofski, Liise-Anne ;

Casadevall, Arturo .

BMC MICROBIOLOGY, 2009, 9

[4]

[Anonymous], 1980, Chin Med J (Engl), V93, P123

[5] Carbonic anhydrase and CO2 sensing during Cryptocloccus neoformans growth, differentiation, and virulence [J].

Bahn, YS ;

Cox, GM ;

Perfect, JR ;

Heitman, J .

CURRENT BIOLOGY, 2005, 15 (22) :2013-2020

[6] Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans [J].

Baker, Lorina G. ;

Specht, Charles A. ;

Donlin, Maureen J. ;

Lodge, Jennifer K. .

EUKARYOTIC CELL, 2007, 6 (05) :855-867

[7] Chitinases Are Essential for Sexual Development but Not Vegetative Growth in Cryptococcus neoformans [J].

Baker, Lorina G. ;

Specht, Charles A. ;

Lodge, Jennifer K. .

EUKARYOTIC CELL, 2009, 8 (11) :1692-1705

[8] A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans [J].

Banks, IR ;

Specht, CA ;

Donlin, MJ ;

Gerik, KJ ;

Levitz, SM ;

Lodge, JK .

EUKARYOTIC CELL, 2005, 4 (11) :1902-1912

[9] Functional cloning and characterization of a UDP-glucuronic acid decarboxylase:: The pathogenic fungus Cryptococcus neoformans elucidates UDP-xylose synthesis [J].

Bar-Peled, M ;

Griffith, CL ;

Doering, TL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :12003-12008

[10]

BARRETTBEE K, 1985, J GEN MICROBIOL, V131, P1217

← 1 2 3 4 5 6 7 8 9 10 →