MAIT Cells in Barrier Tissues: Lessons from Immediate Neighbors

被引:28
作者
Amini, Ali [1 ,2 ]
Pang, Declan [2 ]
Hackstein, Carl-Philipp [1 ,2 ]
Klenerman, Paul [1 ,2 ]
机构
[1] Univ Oxford, Nuffield Dept Med, Translat Gastroenterol Unit, Oxford, England
[2] Univ Oxford, Peter Medawar Bldg Pathogen Res, Oxford, England
来源
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
基金
英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;
关键词
mucosal-associated invariant T cells; microenvironment; microbiome; metabolism; tissue resident cells; mucosal immunology; diet; INVARIANT T-CELLS; INNATE LYMPHOID-CELLS; ARYL-HYDROCARBON RECEPTOR; CHAIN FATTY-ACIDS; REGULATORY T; VITAMIN-D; 1,25-DIHYDROXYVITAMIN D-3; IL-17; PRODUCTION; SKIN MICROBIOTA; IMMUNE-RESPONSE;
D O I
10.3389/fimmu.2020.584521
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable frequencies in human blood and barrier tissues, armed with an expanding array of effector functions in response to homeostatic perturbations. Analogous to other barrier immune cells, their phenotype and function is driven by crosstalk with host and dynamic environmental factors, most pertinently the microbiome. Given their distribution, they must function in diverse extracellular milieus. Tissue-specific and adapted functions of barrier immune cells are shaped by transcriptional programs and regulated through a blend of local cellular, inflammatory, physiological, and metabolic mediators unique to each microenvironment. This review compares the phenotype and function of MAIT cells with other barrier immune cells, highlighting potential areas for future exploration. Appreciation of MAIT cell biology within tissues is crucial to understanding their niche in health and disease.
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页数:20
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