Fatigue and physical activity in cancer survivors: A cross-sectional population-based study

被引:35
作者
Matias, Margarida [1 ]
Baciarello, Giulia [1 ]
Neji, Mohamed [1 ,2 ]
Di Meglio, Antonio [3 ]
Michiels, Stefan [4 ]
Partridge, Ann H. [5 ]
Bendiane, Marc Karim [6 ]
Fizazi, Karim [1 ]
Ducreux, Michel [1 ]
Andre, Fabrice [1 ,3 ]
Vaz-Luis, Ines [1 ,3 ]
机构
[1] Univ Paris Saclay, Univ Paris Sud, Dept Med Oncol, Gustave Roussy, Villejuif, France
[2] Ctr Hosp Intercommunal Creteil, Dept Med Oncol, Creteil, France
[3] INSERM UMR 981, Gustave Roussy, Villejuif, France
[4] Univ Paris Saclay, Univ Paris Sud, Dept Biostat & Epidemiol, Gustave Roussy, Villejuif, France
[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[6] INSERM UMR912, Provence Alpes Cote dAzur Reg Hlth Observ, Marseille, France
来源
CANCER MEDICINE | 2019年 / 8卷 / 05期
关键词
cancer; fatigue; physical activity; quality of life; survivorship; QUALITY-OF-LIFE; PERSISTENT FATIGUE; BREAST; PREVALENCE; PREDICTORS; RADIOTHERAPY; STATISTICS; VALIDATION; DEPRESSION; OUTCOMES;
D O I
10.1002/cam4.2060
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose A substantial proportion of cancer survivors experience fatigue after diagnosis. Physical activity (PA) can impact fatigue after cancer. In this study, we evaluated the prevalence and association of fatigue and the practice of PA in a population with early cancer. Methods Using the national population-based French cross-sectional study Vie apres le cancer 2, we included 1984 patients with early breast (61.1%), prostate (21.5%), and colorectal (17.4%) cancer. Severe fatigue at 2 years postdiagnosis was defined by a score >= 40 in the European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ C30) fatigue subscale. PA was defined as (a) self-reported PA before diagnosis (active/inactive) and (b) change in PA since diagnosis (increased/maintained exposure vs decreased exposure/remaining inactive). Multivariate regression examined associations of severe fatigue with PA, adjusting for baseline clinical and treatment variables. Results Median age was 52 years. 51.5% of patients experienced severe fatigue 2 years post-diagnosis. 87.7% reported to be physically active before cancer diagnosis; 53.3% of patients either decreased PA or remained inactive at 2 years postdiagnosis. At 2 years postdiagnosis, severe fatigue was associated with a change in PA since diagnosis: patients with decreasing PA/remaining inactive from pre- to postdiagnosis had a higher risk of severe fatigue vs those with increasing/maintaining PA (adjusted odds ratio [95% confidence interval] 2.32 [1.85-2.90]). Conclusion Fatigue continues to be a substantial problem for cancer survivors 2 years after cancer diagnosis and is associated with PA decreasing/remaining inactive since diagnosis. Interventions to maintain or increase PA for cancer survivors should be tested to mitigate long-term fatigue after cancer.
引用
收藏
页码:2535 / 2544
页数:10
相关论文
共 42 条
[1]   Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors [J].
Abrahams, H. J. G. ;
Gielissen, M. F. M. ;
Schmits, I. C. ;
Verhagen, C. A. H. H. V. M. ;
Rovers, M. M. ;
Knoop, H. .
ANNALS OF ONCOLOGY, 2016, 27 (06) :965-974
[2]   A comparison of the characteristics of disease-free breast cancer survivors with or without cancer-related fatigue syndrome [J].
Alexander, S. ;
Minton, O. ;
Andrews, P. ;
Stone, P. .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (03) :384-392
[3]   Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors [J].
Alfano, Catherine M. ;
Imayama, Ikuyo ;
Neuhouser, Marian L. ;
Kiecolt-Glaser, Janice K. ;
Smith, Ashley Wilder ;
Meeske, Kathleen ;
McTiernan, Anne ;
Bernstein, Leslie ;
Baumgartner, Kathy B. ;
Ulrich, Cornelia M. ;
Ballard-Barbash, Rachel .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (12) :1280-1287
[4]   The relationship between fatigue and sleep in cancer patients: a review [J].
Ancoli-Israel, S ;
Moore, PJ ;
Jones, V .
EUROPEAN JOURNAL OF CANCER CARE, 2001, 10 (04) :245-255
[5]   Prevalence, Predictors, and Characteristics of Off-Treatment Fatigue in Breast Cancer Survivors [J].
Andrykowski, Michael A. ;
Donovan, Kristine A. ;
Laronga, Christine ;
Jacobsen, Paul B. .
CANCER, 2010, 116 (24) :5740-5748
[6]  
[Anonymous], COCHRANE DB SYST REV
[7]  
Berger A M, 1998, Oncol Nurs Forum, V25, P51
[8]   Cancer-Related Fatigue [J].
Berger, Ann M. ;
Abernethy, Amy Pickar ;
Atkinson, Ashley ;
Barsevick, Andrea M. ;
Breitbart, William S. ;
Cella, David ;
Cimprich, Bernadine ;
Cleeland, Charles ;
Eisenberger, Mario A. ;
Escalante, Carmen P. ;
Jacobsen, Paul B. ;
Kaldor, Phyllis ;
Ligibel, Jennifer A. ;
Murphy, Barbara A. ;
O'Connor, Tracey ;
Pirl, William F. ;
Rodler, Eve ;
Rugo, Hope S. ;
Thomas, Jay ;
Wagner, Lynne I. .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2010, 8 (08) :904-931
[9]   Cancer survivors' adherence to lifestyle behavior recommendations and associations with health-related quality of life: Results from the American Cancer Society's SCS-II [J].
Blanchard, Christopher M. ;
Courneya, Kerry S. ;
Stein, Kevin .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (13) :2198-2204
[10]   The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey) [J].
Bouhnik, Anne-Deborah ;
Bendiane, Marc-Karim ;
Cortaredona, Sebastien ;
Teyssier, Luis Sagaon ;
Rey, Dominique ;
Berenger, Cyril ;
Seror, Valerie ;
Peretti-Watel, Patrick .
BMJ OPEN, 2015, 5 (03)