Diterpenoids from the fruits of Vitex agnus-castus

被引：56

作者：

Hoberg, E

Orjala, J

Meier, B

Sticher, O ^{[1
]}

机构：

[1] Swiss Fed Inst Technol ETH Zurich, Dept Pharm, CH-8057 Zurich, Switzerland

[2] Zellar AG, Herbal Remedies, CH-8590 Romanshorn, Switzerland

来源：

PHYTOCHEMISTRY | 1999年 / 52卷 / 08期

关键词：

Vitex agnus-castus L; Verbenaceae; vitexilactone; rotundifuran; 6 beta,7 beta-diacetoxy-13-hydroxy-labda-8,14-diene dopamine-D-2-receptor affinity;

D O I：

10.1016/S0031-9422(99)00181-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the fruits of Vitex agnus-castus L. one new diterpene, 6 beta,7 beta-diacetoxy-13-hydroxy-labda-8,14-diene, as well as two previously described diterpenes (rotundifuran and vitexilactone) were isolated. All obtained diterpenoids belong to the labdane typ. The structures determinations were mainly based on 1D and 2D NMR spectra and MS data interpretation. 6 beta,7 beta-diacetoxy-13-hydroxy-labda-8,14-diene and rotundifuran showed an affinity to the dopamine-D-2-receptor. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1555 / 1558

页数：4

共 8 条

[1]

ABEL G, 1994, HAGERS HDB PHARM PRA, V6, P1183

[2] CONSTITUENT OF VITEX-ROTUNDIFOLIA L FIL [J].