Cytokine Profiles Differentiate Symptomatic from Asymptomatic PTSD in Service Members and Veterans with Chronic Traumatic Brain Injury

被引：2

作者：

Smith, Ethan G. ^{[1
]}

Hentig, James ^{[2
,3
,4
]}

Martin, Carina ^{[1
,5
]}

Wagner, Chelsea ^{[1
,6
]}

Guedes, Vivian A. ^{[1
]}

Edwards, Katie A. ^{[1
]}

Devoto, Christina ^{[1
,7
]}

Dunbar, Kerri ^{[5
,7
,8
]}

Roy, Michael J. ^{[5
,7
]}

Gill, Jessica M. ^{[5
,6
]}

机构：

[1] NIH, Natl Inst Nursing Res, Bethesda, MD 20892 USA

[2] Traumat Brain Injury Ctr Excellence TBI CoE, Def Hlth Agcy, Res & Dev Directorate J 9, Ft Carson, CO 80913 USA

[3] Evans Army Community Hosp, Intrepid Spirit Ctr, Ft Carson, CO 80913 USA

[4] Gen Dynam Informat Technol, Falls Church, VA 22042 USA

[5] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA

[6] Johns Hopkins Univ, Sch Nursing & Med, Baltimore, MD 21205 USA

[7] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA

[8] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD 20817 USA

来源：

BIOMEDICINES | 2022年 / 10卷 / 12期

关键词：

military; TBI; cytokines; IL-8; PTSD; inflammation; POSTTRAUMATIC-STRESS-DISORDER; RISK; INTERLEUKIN-8; DEPRESSION; IL-8; ALPHA; IRAQ;

D O I：

10.3390/biomedicines10123289

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traumatic brain injuries (TBI) and posttraumatic stress disorder (PTSD) are commonly observed comorbid occurrences among military service members and veterans (SMVs). In this cross-sectional study, SMVs with a history of TBI were stratified into symptomatic and asymptomatic PTSD groups based on posttraumatic stress checklist-civilian (PCL-C) total scores. Blood-based biomarkers were assessed, and significant differential markers were associated with scores from multiple neurobehavioral self-report assessments. PCL-C cutoffs were total scores >50 (PTSD symptomatic) and <25 (asymptomatic). Cytokines IL6, IL8, TNF alpha, and IL10 were significantly elevated (p < 0.05-0.001) in the TBI+/PTSD symptomatic group compared to the TBI+/asymptomatic group. Cytokine levels of IL8, TNF alpha, and IL10 were strongly associated with PCL-C scores (0.356 < r > 0.624 for all, p < 0.01 for all), while TNF alpha and IL10 were additionally associated with NSI totals (r = 0.285 and r = 0.270, p < 0.05, respectively). This is the first study focused on PTSD symptom severity to report levels of circulating pro-inflammatory IL8, specifically in SMVs with TBI. These data suggest that within the military TBI population, there are unique cytokine profiles that relate to neurobehavioral outcomes associated with TBI and PTSD.

引用

页数：11

共 42 条

[1]

ALOISI F, 1992, J IMMUNOL, V149, P2358

[2] Evaluating the Cross-Sectional and Longitudinal Relationships Predicting Suicidal Ideation Following Traumatic Brain Injury [J].