Escherichia coli Dysbiosis Correlates With Gastrointestinal Dysfunction in Children With Cystic Fibrosis

被引：75

作者：

Hoffman, Lucas R. ^{[1
,2
,6
]}

Pope, Christopher E. ^{[1
]}

Hayden, Hillary S. ^{[2
]}

Heltshe, Sonya ^{[1
,6
]}

Levy, Roie ^{[3
]}

McNamara, Sharon ^{[6
]}

Jacobs, Michael A. ^{[2
,3
]}

Rohmer, Laurence ^{[2
]}

Radey, Matthew ^{[2
]}

Ramsey, Bonnie W. ^{[1
,6
]}

Brittnacher, Mitchell J. ^{[2
]}

Borenstein, Elhanan ^{[3
,4
,7
]}

Miller, Samuel I. ^{[2
,5
]}

机构：

[1] Univ Washington, Dept Pediat, Seattle, WA 98105 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98105 USA

[3] Univ Washington, Dept Genome Sci, Seattle, WA 98105 USA

[4] Univ Washington, Dept Comp Sci & Engn, Seattle, WA 98105 USA

[5] Univ Washington, Dept Med, Seattle, WA 98105 USA

[6] Seattle Childrens Hosp, Washington, DC USA

[7] Santa Fe Inst, Santa Fe, NM USA

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 03期

基金：

美国国家卫生研究院;

关键词：

cystic fibrosis; microbiota; Escherichia coli; inflammation; malabsorption; MICROBIOTA;

D O I：

10.1093/cid/cit715

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

引用

页码：396 / 399

页数：4

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